IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-02926-5.html
   My bibliography  Save this article

A transcriptomic atlas of aged human microglia

Author

Listed:
  • Marta Olah

    (Columbia University Medical Center
    Broad Institute)

  • Ellis Patrick

    (The University of Sydney)

  • Alexandra-Chloe Villani

    (Broad Institute
    Massachusetts General Hospital)

  • Jishu Xu

    (Broad Institute)

  • Charles C. White

    (Broad Institute)

  • Katie J. Ryan

    (Harvard Medical School)

  • Paul Piehowski

    (Pacific Northwest National Laboratory)

  • Alifiya Kapasi

    (Pacific Northwest National Laboratory)

  • Parham Nejad

    (Broad Institute)

  • Maria Cimpean

    (Harvard Medical School)

  • Sarah Connor

    (Columbia University Medical Center
    Broad Institute)

  • Christina J. Yung

    (Columbia University Medical Center)

  • Michael Frangieh

    (Harvard Medical School)

  • Allison McHenry

    (Harvard Medical School)

  • Wassim Elyaman

    (Columbia University Medical Center
    Broad Institute)

  • Vlad Petyuk

    (Pacific Northwest National Laboratory)

  • Julie A. Schneider

    (Rush University Medical Center)

  • David A. Bennett

    (Rush University Medical Center)

  • Philip L. De Jager

    (Columbia University Medical Center
    Broad Institute)

  • Elizabeth M. Bradshaw

    (Columbia University Medical Center
    Broad Institute)

Abstract

With a rapidly aging global human population, finding a cure for late onset neurodegenerative diseases has become an urgent enterprise. However, these efforts are hindered by the lack of understanding of what constitutes the phenotype of aged human microglia—the cell type that has been strongly implicated by genetic studies in the pathogenesis of age-related neurodegenerative disease. Here, we establish the set of genes that is preferentially expressed by microglia in the aged human brain. This HuMi_Aged gene set captures a unique phenotype, which we confirm at the protein level. Furthermore, we find this gene set to be enriched in susceptibility genes for Alzheimer’s disease and multiple sclerosis, to be increased with advancing age, and to be reduced by the protective APOEε2 haplotype. APOEε4 has no effect. These findings confirm the existence of an aging-related microglial phenotype in the aged human brain and its involvement in the pathological processes associated with brain aging.

Suggested Citation

  • Marta Olah & Ellis Patrick & Alexandra-Chloe Villani & Jishu Xu & Charles C. White & Katie J. Ryan & Paul Piehowski & Alifiya Kapasi & Parham Nejad & Maria Cimpean & Sarah Connor & Christina J. Yung &, 2018. "A transcriptomic atlas of aged human microglia," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-02926-5
    DOI: 10.1038/s41467-018-02926-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-02926-5
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-02926-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Zu-Qiang Liu & Hao Dai & Lu Yao & Wei-Feng Chen & Yun Wang & Li-Yun Ma & Xiao-Qing Li & Sheng-Li Lin & Meng-Jiang He & Ping-Ting Gao & Xin-Yang Liu & Jia-Xin Xu & Xiao-Yue Xu & Ke-Hao Wang & Li Wang &, 2023. "A single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasia," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Thomas S. Wingo & Yue Liu & Ekaterina S. Gerasimov & Selina M. Vattathil & Meghan E. Wynne & Jiaqi Liu & Adriana Lori & Victor Faundez & David A. Bennett & Nicholas T. Seyfried & Allan I. Levey & Aliz, 2022. "Shared mechanisms across the major psychiatric and neurodegenerative diseases," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-02926-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.