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CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells

Author

Listed:
  • K. Oleinika

    (University College London
    University College London)

  • E. C. Rosser

    (University College London
    University College London)

  • D. E. Matei

    (University College London)

  • K. Nistala

    (University College London)

  • A. Bosma

    (University College London)

  • I. Drozdov

    (Bering Limited)

  • C. Mauri

    (University College London)

Abstract

Regulatory B cells (Breg) express high levels of CD1d that presents lipid antigens to invariant natural killer T (iNKT) cells. The function of CD1d in Breg biology and iNKT cell activity during inflammation remains unclear. Here we show, using chimeric mice, cell depletion and adoptive cell transfer, that CD1d–lipid presentation by Bregs induces iNKT cells to secrete interferon (IFN)-γ to contribute, partially, to the downregulation of T helper (Th)1 and Th17-adaptive immune responses and ameliorate experimental arthritis. Mice lacking CD1d-expressing B cells develop exacerbated disease compared to wild-type mice, and fail to respond to treatment with the prototypical iNKT cell agonist α-galactosylceramide. The absence of lipid presentation by B cells alters iNKT cell activation with disruption of metabolism regulation and cytokine responses. Thus, we identify a mechanism by which Bregs restrain excessive inflammation via lipid presentation.

Suggested Citation

  • K. Oleinika & E. C. Rosser & D. E. Matei & K. Nistala & A. Bosma & I. Drozdov & C. Mauri, 2018. "CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-02911-y
    DOI: 10.1038/s41467-018-02911-y
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    Cited by:

    1. Channakeshava Sokke Umeshappa & Patricia Solé & Jun Yamanouchi & Saswat Mohapatra & Bas G. J. Surewaard & Josep Garnica & Santiswarup Singha & Debajyoti Mondal & Elena Cortés-Vicente & Charlotte D’Mel, 2022. "Re-programming mouse liver-resident invariant natural killer T cells for suppressing hepatic and diabetogenic autoimmunity," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Moriya Tsuji & Manoj S. Nair & Kazuya Masuda & Candace Castagna & Zhenlu Chong & Tamarand L. Darling & Kuljeet Seehra & Youngmin Hwang & Ágata Lopes Ribeiro & Geovane Marques Ferreira & Laura Corredor, 2023. "An immunostimulatory glycolipid that blocks SARS-CoV-2, RSV, and influenza infections in vivo," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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