IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-02865-1.html
   My bibliography  Save this article

Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells

Author

Listed:
  • Naohiro Seo

    (Mie University Graduate School of Medicine
    Japan Science and Technology Agency (JST))

  • Yoshitaka Shirakura

    (Mie University Graduate School of Medicine)

  • Yoshiro Tahara

    (Japan Science and Technology Agency (JST)
    Kyushu University)

  • Fumiyasu Momose

    (Mie University Graduate School of Medicine
    Japan Science and Technology Agency (JST))

  • Naozumi Harada

    (Mie University Graduate School of Medicine
    Japan Science and Technology Agency (JST))

  • Hiroaki Ikeda

    (Nagasaki University Graduate School of Biomedical Sciences)

  • Kazunari Akiyoshi

    (Japan Science and Technology Agency (JST)
    Kyoto University)

  • Hiroshi Shiku

    (Mie University Graduate School of Medicine
    Japan Science and Technology Agency (JST))

Abstract

Fibroblastic tumour stroma comprising mesenchymal stem cells (MSCs) and cancer-associated fibroblasts (CAFs) promotes the invasive and metastatic properties of tumour cells. Here we show that activated CD8+ T cell-derived extracellular vesicles (EVs) interrupt fibroblastic stroma-mediated tumour progression. Activated CD8+ T cells from healthy mice transiently release cytotoxic EVs causing marked attenuation of tumour invasion and metastasis by apoptotic depletion of mesenchymal tumour stromal cells. Infiltration of EV-producing CD8+ T cells is observed in neovascular areas with high mesenchymal cell density, and tumour MSC depletion is associated with preferential engulfment of CD8+ T cell EVs in this setting. Thus, CD8+ T cells have the capacity to protect tumour progression by EV-mediated depletion of mesenchymal tumour stromal cells in addition to their conventional direct cytotoxicity against tumour cells.

Suggested Citation

  • Naohiro Seo & Yoshitaka Shirakura & Yoshiro Tahara & Fumiyasu Momose & Naozumi Harada & Hiroaki Ikeda & Kazunari Akiyoshi & Hiroshi Shiku, 2018. "Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells," Nature Communications, Nature, vol. 9(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-02865-1
    DOI: 10.1038/s41467-018-02865-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-02865-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-02865-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-02865-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.