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Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer

Author

Listed:
  • Tesa M. Severson

    (Oncode Institute, Netherlands Cancer Institute)

  • Yongsoo Kim

    (Oncode Institute, Netherlands Cancer Institute
    Oncode Institute, Netherlands Cancer Institute)

  • Stacey E. P. Joosten

    (Oncode Institute, Netherlands Cancer Institute)

  • Karianne Schuurman

    (Oncode Institute, Netherlands Cancer Institute)

  • Petra van der Groep

    (University Medical Center)

  • Cathy B. Moelans

    (University Medical Center)

  • Natalie D. ter Hoeve

    (University Medical Center)

  • Quirine F. Manson

    (University Medical Center)

  • John W. Martens

    (Dutch Breast Cancer Research Group, (BOOG Study Center)
    Erasmus Medical Center
    Cancer Genomics Netherlands)

  • Carolien H. M. van Deurzen

    (Dutch Breast Cancer Research Group, (BOOG Study Center)
    Erasmus Medical Center)

  • Ellis Barbe

    (Dutch Breast Cancer Research Group, (BOOG Study Center)
    VU Medical Center (VUMC))

  • Ingrid Hedenfalk

    (Lund University)

  • Peter Bult

    (Radboud University Medical Center)

  • Vincent T. H. B. M. Smit

    (Dutch Breast Cancer Research Group, (BOOG Study Center)
    Leiden University Medical Centre)

  • Sabine C. Linn

    (University Medical Center
    Netherlands Cancer Institute
    Netherlands Cancer Institute)

  • Paul J. van Diest

    (University Medical Center)

  • Lodewyk Wessels

    (Oncode Institute, Netherlands Cancer Institute
    Cancer Genomics Netherlands
    Delft University of Technology)

  • Wilbert Zwart

    (Oncode Institute, Netherlands Cancer Institute)

Abstract

Male breast cancer (MBC) is rare and poorly characterized. Like the female counterpart, most MBCs are hormonally driven, but relapse after hormonal treatment is also noted. The pan-hormonal action of steroid hormonal receptors, including estrogen receptor alpha (ERα), androgen receptor (AR), progesterone receptor (PR), and glucocorticoid receptor (GR) in this understudied tumor type remains wholly unexamined. This study reveals genomic cross-talk of steroid hormone receptor action and interplay in human tumors, here in the context of MBC, in relation to the female disease and patient outcome. Here we report the characterization of human breast tumors of both genders for cistromic make-up of hormonal regulation in human tumors, revealing genome-wide chromatin binding landscapes of ERα, AR, PR, GR, FOXA1, and GATA3 and enhancer-enriched histone mark H3K4me1. We integrate these data with transcriptomics to reveal gender-selective and genomic location-specific hormone receptor actions, which associate with survival in MBC patients.

Suggested Citation

  • Tesa M. Severson & Yongsoo Kim & Stacey E. P. Joosten & Karianne Schuurman & Petra van der Groep & Cathy B. Moelans & Natalie D. ter Hoeve & Quirine F. Manson & John W. Martens & Carolien H. M. van De, 2018. "Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-02856-2
    DOI: 10.1038/s41467-018-02856-2
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    Cited by:

    1. Handong Sun & Lishen Zhang & Zhonglin Wang & Danling Gu & Mengyan Zhu & Yun Cai & Lu Li & Jiaqi Tang & Bin Huang & Bakwatanisa Bosco & Ning Li & Lingxiang Wu & Wei Wu & Liangyu Li & Yuan Liang & Lin L, 2023. "Single-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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