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A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression

Author

Listed:
  • Guermarie Velazquez-Torres

    (Unit 1906, The University of Texas MD Anderson Cancer Center)

  • Einav Shoshan

    (Unit 1906, The University of Texas MD Anderson Cancer Center)

  • Cristina Ivan

    (Unit 1362, The University of Texas MD Anderson Cancer Center)

  • Li Huang

    (Unit 1906, The University of Texas MD Anderson Cancer Center)

  • Enrique Fuentes-Mattei

    (Unit 1950, The University of Texas MD Anderson Cancer Center)

  • Harrison Paret

    (Unit 1906, The University of Texas MD Anderson Cancer Center)

  • Sun Jin Kim

    (Unit 1906, The University of Texas MD Anderson Cancer Center)

  • Cristian Rodriguez-Aguayo

    (Unit 1950, The University of Texas MD Anderson Cancer Center)

  • Victoria Xie

    (The University of Texas MD Anderson Cancer Center)

  • Denise Brooks

    (Canada’s Michael Smith Cancer Agency)

  • Steven J. M. Jones

    (Canada’s Michael Smith Cancer Agency)

  • A. Gordon Robertson

    (Canada’s Michael Smith Cancer Agency)

  • George Calin

    (Unit 1950, The University of Texas MD Anderson Cancer Center)

  • Gabriel Lopez-Berenstein

    (Unit 1950, The University of Texas MD Anderson Cancer Center)

  • Anil Sood

    (Unit 1362, The University of Texas MD Anderson Cancer Center)

  • Menashe Bar-Eli

    (Unit 1906, The University of Texas MD Anderson Cancer Center)

Abstract

Previously we have reported that metastatic melanoma cell lines and tumor specimens have reduced expression of ADAR1 and consequently are impaired in their ability to perform A-to-I microRNA (miRNA) editing. The effects of A-to-I miRNAs editing on melanoma growth and metastasis are yet to be determined. Here we report that miR-378a–3p is undergoing A-to-I editing only in the non-metastatic but not in metastatic melanoma cells. The function of the edited form is different from its wild-type counterpart. The edited form of miR-378a-3p preferentially binds to the 3′-UTR of the PARVA oncogene and inhibits its expression, thus preventing the progression of melanoma towards the malignant phenotype. Indeed, edited miR-378a-3p but not its WT form inhibits melanoma metastasis in vivo. These results further emphasize the role of RNA editing in melanoma progression.

Suggested Citation

  • Guermarie Velazquez-Torres & Einav Shoshan & Cristina Ivan & Li Huang & Enrique Fuentes-Mattei & Harrison Paret & Sun Jin Kim & Cristian Rodriguez-Aguayo & Victoria Xie & Denise Brooks & Steven J. M. , 2018. "A-to-I miR-378a-3p editing can prevent melanoma progression via regulation of PARVA expression," Nature Communications, Nature, vol. 9(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-02851-7
    DOI: 10.1038/s41467-018-02851-7
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