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DNA-assisted swarm control in a biomolecular motor system

Author

Listed:
  • Jakia Jannat Keya

    (Hokkaido University)

  • Ryuhei Suzuki

    (Hokkaido University)

  • Arif Md. Rashedul Kabir

    (Hokkaido University)

  • Daisuke Inoue

    (Hokkaido University)

  • Hiroyuki Asanuma

    (Nagoya University)

  • Kazuki Sada

    (Hokkaido University
    Hokkaido University)

  • Henry Hess

    (Columbia University)

  • Akinori Kuzuya

    (Kansai University)

  • Akira Kakugo

    (Hokkaido University
    Hokkaido University
    Columbia University)

Abstract

In nature, swarming behavior has evolved repeatedly among motile organisms because it confers a variety of beneficial emergent properties. These include improved information gathering, protection from predators, and resource utilization. Some organisms, e.g., locusts, switch between solitary and swarm behavior in response to external stimuli. Aspects of swarming behavior have been demonstrated for motile supramolecular systems composed of biomolecular motors and cytoskeletal filaments, where cross-linkers induce large scale organization. The capabilities of such supramolecular systems may be further extended if the swarming behavior can be programmed and controlled. Here, we demonstrate that the swarming of DNA-functionalized microtubules (MTs) propelled by surface-adhered kinesin motors can be programmed and reversibly regulated by DNA signals. Emergent swarm behavior, such as translational and circular motion, can be selected by tuning the MT stiffness. Photoresponsive DNA containing azobenzene groups enables switching between solitary and swarm behavior in response to stimulation with visible or ultraviolet light.

Suggested Citation

  • Jakia Jannat Keya & Ryuhei Suzuki & Arif Md. Rashedul Kabir & Daisuke Inoue & Hiroyuki Asanuma & Kazuki Sada & Henry Hess & Akinori Kuzuya & Akira Kakugo, 2018. "DNA-assisted swarm control in a biomolecular motor system," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02778-5
    DOI: 10.1038/s41467-017-02778-5
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    Cited by:

    1. Shuqin Chen & Xander Peetroons & Anna C. Bakenecker & Florencia Lezcano & Igor S. Aranson & Samuel Sánchez, 2024. "Collective buoyancy-driven dynamics in swarming enzymatic nanomotors," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    2. Woo Hyuk Jung & Jin Hyuk Park & Seokho Kim & Chunzhi Cui & Dong June Ahn, 2022. "Molecular doping of nucleic acids into light emitting crystals driven by multisite-intermolecular interaction," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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