IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-017-02753-0.html
   My bibliography  Save this article

Closed-loop stimulation of temporal cortex rescues functional networks and improves memory

Author

Listed:
  • Youssef Ezzyat

    (University of Pennsylvania)

  • Paul A. Wanda

    (University of Pennsylvania)

  • Deborah F. Levy

    (University of Pennsylvania)

  • Allison Kadel

    (University of Pennsylvania)

  • Ada Aka

    (University of Pennsylvania)

  • Isaac Pedisich

    (University of Pennsylvania)

  • Michael R. Sperling

    (Thomas Jefferson University Hospital)

  • Ashwini D. Sharan

    (Thomas Jefferson University Hospital)

  • Bradley C. Lega

    (University of Texas, Southwestern)

  • Alexis Burks

    (University of Texas, Southwestern)

  • Robert E. Gross

    (Emory University Hospital)

  • Cory S. Inman

    (Emory University Hospital)

  • Barbara C. Jobst

    (Dartmouth-Hitchcock Medical Center)

  • Mark A. Gorenstein

    (Dartmouth-Hitchcock Medical Center)

  • Kathryn A. Davis

    (Hospital of the University of Pennsylvania)

  • Gregory A. Worrell

    (Mayo Clinic)

  • Michal T. Kucewicz

    (Mayo Clinic)

  • Joel M. Stein

    (Hospital of the University of Pennsylvania)

  • Richard Gorniak

    (Thomas Jefferson University Hospital)

  • Sandhitsu R. Das

    (Hospital of the University of Pennsylvania)

  • Daniel S. Rizzuto

    (University of Pennsylvania)

  • Michael J. Kahana

    (University of Pennsylvania)

Abstract

Memory failures are frustrating and often the result of ineffective encoding. One approach to improving memory outcomes is through direct modulation of brain activity with electrical stimulation. Previous efforts, however, have reported inconsistent effects when using open-loop stimulation and often target the hippocampus and medial temporal lobes. Here we use a closed-loop system to monitor and decode neural activity from direct brain recordings in humans. We apply targeted stimulation to lateral temporal cortex and report that this stimulation rescues periods of poor memory encoding. This system also improves later recall, revealing that the lateral temporal cortex is a reliable target for memory enhancement. Taken together, our results suggest that such systems may provide a therapeutic approach for treating memory dysfunction.

Suggested Citation

  • Youssef Ezzyat & Paul A. Wanda & Deborah F. Levy & Allison Kadel & Ada Aka & Isaac Pedisich & Michael R. Sperling & Ashwini D. Sharan & Bradley C. Lega & Alexis Burks & Robert E. Gross & Cory S. Inman, 2018. "Closed-loop stimulation of temporal cortex rescues functional networks and improves memory," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02753-0
    DOI: 10.1038/s41467-017-02753-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-017-02753-0
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-017-02753-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Denis Demin & Liliya Poskotinova, 2022. "Neurophysiologic Reactions during Heart Rate Variability Biofeedback Session in Adolescents with Different Risk of Internet Addiction," IJERPH, MDPI, vol. 19(5), pages 1-9, February.
    2. Yuhao Huang & Rina Zelmann & Peter Hadar & Jaquelin Dezha-Peralta & R. Mark Richardson & Ziv M. Williams & Sydney S. Cash & Corey J. Keller & Angelique C. Paulk, 2024. "Theta-burst direct electrical stimulation remodels human brain networks," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Yuxuan Li & Jesse K. Pazdera & Michael J. Kahana, 2024. "EEG decoders track memory dynamics," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02753-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.