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Culex pipiens crossing type diversity is governed by an amplified and polymorphic operon of Wolbachia

Author

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  • Manon Bonneau

    (UMR CNRS-IRD-EPHE-Université de Montpellier)

  • Celestine Atyame

    (UMR CNRS-IRD-EPHE-Université de Montpellier
    UMR CNRS-INSERM-IRD-Université de La Réunion)

  • Marwa Beji

    (University of Tunis El Manar)

  • Fabienne Justy

    (UMR CNRS-IRD-EPHE-Université de Montpellier)

  • Martin Cohen-Gonsaud

    (UMR CNRS-INSERM-Université de Montpellier)

  • Mathieu Sicard

    (UMR CNRS-IRD-EPHE-Université de Montpellier)

  • Mylène Weill

    (UMR CNRS-IRD-EPHE-Université de Montpellier)

Abstract

Culex pipiens mosquitoes are infected with Wolbachia (wPip) that cause an important diversity of cytoplasmic incompatibilities (CIs). Functional transgenic studies have implicated the cidA-cidB operon from wPip and its homolog in wMel in CI between infected Drosophila males and uninfected females. However, the genetic basis of the CI diversity induced by different Wolbachia strains was unknown. We show here that the remarkable diversity of CI in the C. pipiens complex is due to the presence, in all tested wPip genomes, of several copies of the cidA-cidB operon, which undergoes diversification through recombination events. In 183 isofemale lines of C. pipiens collected worldwide, specific variations of the cidA-cidB gene repertoires are found to match crossing types. The diversification of cidA-cidB is consistent with the hypothesis of a toxin–antitoxin system in which the gene cidB co-diversifies with the gene cidA, particularly in putative domains of reciprocal interactions.

Suggested Citation

  • Manon Bonneau & Celestine Atyame & Marwa Beji & Fabienne Justy & Martin Cohen-Gonsaud & Mathieu Sicard & Mylène Weill, 2018. "Culex pipiens crossing type diversity is governed by an amplified and polymorphic operon of Wolbachia," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02749-w
    DOI: 10.1038/s41467-017-02749-w
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    Cited by:

    1. Haofeng Wang & Yunjie Xiao & Xia Chen & Mengwen Zhang & Guangxin Sun & Feng Wang & Lin Wang & Hanxiao Zhang & Xiaoyu Zhang & Xin Yang & Wenling Li & Yi Wei & Deqiang Yao & Bing Zhang & Jun Li & Wen Cu, 2022. "Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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