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Pushing nuclear magnetic resonance sensitivity limits with microfluidics and photo-chemically induced dynamic nuclear polarization

Author

Listed:
  • Miguel Mompeán

    (Avda Camilo José Cela s/n)

  • Rosa M. Sánchez-Donoso

    (Avda Camilo José Cela s/n
    Wageningen University)

  • Antonio Hoz

    (Avda Camilo José Cela s/n)

  • Vittorio Saggiomo

    (Wageningen University)

  • Aldrik H. Velders

    (Avda Camilo José Cela s/n
    Wageningen University
    Wageningen University & Research)

  • M. Victoria Gomez

    (Avda Camilo José Cela s/n)

Abstract

Among the methods to enhance the sensitivity of nuclear magnetic resonance (NMR) spectroscopy, small-diameter NMR coils (microcoils) are promising tools to tackle the study of mass-limited samples. Alternatively, hyperpolarization schemes based on dynamic nuclear polarization techniques provide strong signal enhancements of the NMR target samples. Here we present a method to effortlessly perform photo-chemically induced dynamic nuclear polarization in microcoil setups to boost NMR signal detection down to sub-picomole detection limits in a 9.4T system (400 MHz 1H Larmor frequency). This setup is unaffected by current major drawbacks such as the use of high-power light sources to attempt uniform irradiation of the sample, and accumulation of degraded photosensitizer in the detection region. The latter is overcome with flow conditions, which in turn open avenues for complex applications requiring rapid and efficient mixing that are not easily achievable on an NMR tube without resorting to complex hardware.

Suggested Citation

  • Miguel Mompeán & Rosa M. Sánchez-Donoso & Antonio Hoz & Vittorio Saggiomo & Aldrik H. Velders & M. Victoria Gomez, 2018. "Pushing nuclear magnetic resonance sensitivity limits with microfluidics and photo-chemically induced dynamic nuclear polarization," Nature Communications, Nature, vol. 9(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02575-0
    DOI: 10.1038/s41467-017-02575-0
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    Cited by:

    1. M. Victoria Gomez & Sander Baas & Aldrik H. Velders, 2023. "Multinuclear 1D and 2D NMR with 19F-Photo-CIDNP hyperpolarization in a microfluidic chip with untuned microcoil," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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