IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-017-02573-2.html
   My bibliography  Save this article

Maturation of the gut microbiome and risk of asthma in childhood

Author

Listed:
  • Jakob Stokholm

    (University of Copenhagen
    New York University Langone Medical Center)

  • Martin J. Blaser

    (New York University Langone Medical Center)

  • Jonathan Thorsen

    (University of Copenhagen)

  • Morten A. Rasmussen

    (University of Copenhagen
    Harvard School of Public Health
    University of Copenhagen)

  • Johannes Waage

    (University of Copenhagen)

  • Rebecca K. Vinding

    (University of Copenhagen)

  • Ann-Marie M. Schoos

    (University of Copenhagen)

  • Asja Kunøe

    (University of Copenhagen)

  • Nadia R. Fink

    (University of Copenhagen)

  • Bo L. Chawes

    (University of Copenhagen)

  • Klaus Bønnelykke

    (University of Copenhagen)

  • Asker D. Brejnrod

    (University of Copenhagen)

  • Martin S. Mortensen

    (University of Copenhagen)

  • Waleed Abu Al-Soud

    (University of Copenhagen)

  • Søren J. Sørensen

    (University of Copenhagen)

  • Hans Bisgaard

    (University of Copenhagen)

Abstract

The composition of the human gut microbiome matures within the first years of life. It has been hypothesized that microbial compositions in this period can cause immune dysregulations and potentially cause asthma. Here we show, by associating gut microbial composition from 16S rRNA gene amplicon sequencing during the first year of life with subsequent risk of asthma in 690 participants, that 1-year-old children with an immature microbial composition have an increased risk of asthma at age 5 years. This association is only apparent among children born to asthmatic mothers, suggesting that lacking microbial stimulation during the first year of life can trigger their inherited asthma risk. Conversely, adequate maturation of the gut microbiome in this period may protect these pre-disposed children.

Suggested Citation

  • Jakob Stokholm & Martin J. Blaser & Jonathan Thorsen & Morten A. Rasmussen & Johannes Waage & Rebecca K. Vinding & Ann-Marie M. Schoos & Asja Kunøe & Nadia R. Fink & Bo L. Chawes & Klaus Bønnelykke & , 2018. "Maturation of the gut microbiome and risk of asthma in childhood," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02573-2
    DOI: 10.1038/s41467-017-02573-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-017-02573-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-017-02573-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Brandon Hickman & Anne Salonen & Alise J. Ponsero & Roosa Jokela & Kaija-Leena Kolho & Willem M. Vos & Katri Korpela, 2024. "Gut microbiota wellbeing index predicts overall health in a cohort of 1000 infants," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    2. Haixu Xu & Xianfu Yi & Zhaohai Cui & Hui Li & Lin Zhu & Lijuan Zhang & JiaLe Chen & Xutong Fan & Pan Zhou & Mulin Jun Li & Ying Yu & Qiang Liu & Dandan Huang & Zhi Yao & Jie Zhou, 2023. "Maternal antibiotic exposure enhances ILC2 activation in neonates via downregulation of IFN1 signaling," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Trine Zachariasen & Jakob Russel & Charisse Petersen & Gisle A. Vestergaard & Shiraz Shah & Pablo Atienza Lopez & Moschoula Passali & Stuart E. Turvey & Søren J. Sørensen & Ole Lund & Jakob Stokholm &, 2024. "MAGinator enables accurate profiling of de novo MAGs with strain-level phylogenies," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    4. Courtney Hoskinson & Darlene L. Y. Dai & Kate L. Bel & Allan B. Becker & Theo J. Moraes & Piushkumar J. Mandhane & B. Brett Finlay & Elinor Simons & Anita L. Kozyrskyj & Meghan B. Azad & Padmaja Subba, 2023. "Delayed gut microbiota maturation in the first year of life is a hallmark of pediatric allergic disease," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Jonathan Thorsen & Xuan Ji Li & Shuang Peng & Rikke Bjersand Sunde & Shiraz A. Shah & Madhumita Bhattacharyya & Casper Sahl Poulsen & Christina Egeø Poulsen & Cristina Leal Rodriguez & Michael Widdows, 2023. "The airway microbiota of neonates colonized with asthma-associated pathogenic bacteria," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02573-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.