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Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

Author

Listed:
  • C. Stremmel

    (Ludwig-Maximilians-Universität
    Ludwig-Maximilians-Universität)

  • R. Schuchert

    (Ludwig-Maximilians-Universität
    Ludwig-Maximilians-Universität)

  • F. Wagner

    (Ludwig-Maximilians-Universität
    Ludwig-Maximilians-Universität)

  • R. Thaler

    (Ludwig-Maximilians-Universität
    Ludwig-Maximilians-Universität)

  • T. Weinberger

    (Ludwig-Maximilians-Universität
    Ludwig-Maximilians-Universität)

  • R. Pick

    (Ludwig-Maximilians-Universität)

  • E. Mass

    (Memorial Sloan Kettering Cancer Center
    University of Bonn)

  • H. C. Ishikawa-Ankerhold

    (Ludwig-Maximilians-Universität
    Ludwig-Maximilians-Universität)

  • A. Margraf

    (Ludwig-Maximilians-Universität)

  • S. Hutter

    (Klinikum der Universität, Ludwig-Maximilians-Universität)

  • R. Vagnozzi

    (Cincinnati Children’s Hospital Medical Center)

  • S. Klapproth

    (Max Planck Institute of Biochemistry)

  • J. Frampton

    (University of Birmingham)

  • S. Yona

    (The Weizmann Institute of Science)

  • C. Scheiermann

    (Ludwig-Maximilians-Universität)

  • J. D. Molkentin

    (Cincinnati Children’s Hospital Medical Center
    Cincinnati Children’s Hospital Medical Center)

  • U. Jeschke

    (Klinikum der Universität, Ludwig-Maximilians-Universität)

  • M. Moser

    (Max Planck Institute of Biochemistry)

  • M. Sperandio

    (Ludwig-Maximilians-Universität)

  • S. Massberg

    (Ludwig-Maximilians-Universität
    Ludwig-Maximilians-Universität
    Partner Site Munich Heart Alliance)

  • F. Geissmann

    (Memorial Sloan Kettering Cancer Center)

  • C. Schulz

    (Ludwig-Maximilians-Universität
    Ludwig-Maximilians-Universität
    Partner Site Munich Heart Alliance)

Abstract

Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which invade the developing embryo and persist by means of local self-renewal. However, the route and characteristics of YS macrophage trafficking during embryogenesis are incompletely understood. Here we show the early migration dynamics of YS-derived macrophage progenitors in vivo using fate mapping and intravital microscopy. From embryonic day 8.5 (E8.5) CX3CR1+ pre-macrophages are present in the mouse YS where they rapidly proliferate and gain access to the bloodstream to migrate towards the embryo. Trafficking of pre-macrophages and their progenitors from the YS to tissues peaks around E10.5, dramatically decreases towards E12.5 and is no longer evident from E14.5 onwards. Thus, YS progenitors use the vascular system during a restricted time window of embryogenesis to invade the growing fetus. These findings close an important gap in our understanding of the development of the innate immune system.

Suggested Citation

  • C. Stremmel & R. Schuchert & F. Wagner & R. Thaler & T. Weinberger & R. Pick & E. Mass & H. C. Ishikawa-Ankerhold & A. Margraf & S. Hutter & R. Vagnozzi & S. Klapproth & J. Frampton & S. Yona & C. Sch, 2018. "Yolk sac macrophage progenitors traffic to the embryo during defined stages of development," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02492-2
    DOI: 10.1038/s41467-017-02492-2
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    Cited by:

    1. Steven Schepanski & Mattia Chini & Veronika Sternemann & Christopher Urbschat & Kristin Thiele & Ting Sun & Yu Zhao & Mareike Poburski & Anna Woestemeier & Marie-Theres Thieme & Dimitra E. Zazara & Ma, 2022. "Pregnancy-induced maternal microchimerism shapes neurodevelopment and behavior in mice," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Xiaowei Gu & Anna Heinrich & Shu-Yun Li & Tony DeFalco, 2023. "Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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