IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-017-02458-4.html
   My bibliography  Save this article

Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota

Author

Listed:
  • Aurélie Durand

    (CNRS UMR8104, INSERM U1016)

  • Alexandra Audemard-Verger

    (CNRS UMR8104, INSERM U1016)

  • Vincent Guichard

    (CNRS UMR8104, INSERM U1016
    Sorbonne Paris Cité)

  • Raphaël Mattiuz

    (CNRS UMR8104, INSERM U1016)

  • Arnaud Delpoux

    (CNRS UMR8104, INSERM U1016)

  • Pauline Hamon

    (Centre d’Immunologie et des Maladies Infectieuses)

  • Nelly Bonilla

    (CNRS UMR8104, INSERM U1016)

  • Matthieu Rivière

    (CNRS UMR8104, INSERM U1016)

  • Jérôme Delon

    (CNRS UMR8104, INSERM U1016)

  • Bruno Martin

    (CNRS UMR8104, INSERM U1016)

  • Cédric Auffray

    (CNRS UMR8104, INSERM U1016)

  • Alexandre Boissonnas

    (Centre d’Immunologie et des Maladies Infectieuses)

  • Bruno Lucas

    (CNRS UMR8104, INSERM U1016)

Abstract

Despite being implicated in non-lymphoid tissues, non-recirculating T cells may also exist in secondary lymphoid organs (SLO). However, a detailed characterization of this lymphoid-resident T cell pool has not yet been done. Here we show that a substantial proportion of CD4 regulatory (Treg) and memory (Tmem) cells establish long-term residence in the SLOs of specific pathogen-free mice. Of these SLOs, only T cell residence within Peyer’s patches is affected by microbiota. Resident CD4 Treg and CD4 Tmem cells from lymph nodes and non-lymphoid tissues share many phenotypic and functional characteristics. The percentage of resident T cells in SLOs increases considerably with age, with S1PR1 downregulation possibly contributing to this altered homeostasis. Our results thus show that T cell residence is not only a hallmark of non-lymphoid tissues, but can be extended to secondary lymphoid organs.

Suggested Citation

  • Aurélie Durand & Alexandra Audemard-Verger & Vincent Guichard & Raphaël Mattiuz & Arnaud Delpoux & Pauline Hamon & Nelly Bonilla & Matthieu Rivière & Jérôme Delon & Bruno Martin & Cédric Auffray & Ale, 2018. "Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02458-4
    DOI: 10.1038/s41467-017-02458-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-017-02458-4
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-017-02458-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02458-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.