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Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination

Author

Listed:
  • Manideep Chavali

    (Stony Brook University
    Stony Brook University
    University of California–San Francisco)

  • Michael Klingener

    (Stony Brook University)

  • Alexandros G. Kokkosis

    (Stony Brook University)

  • Yury Garkun

    (Stony Brook University)

  • Sylwia Felong

    (Stony Brook University)

  • Arianna Maffei

    (Stony Brook University)

  • Adan Aguirre

    (Stony Brook University)

Abstract

Adult neural stem cells (NSCs) reside in a specialized microenvironment, the subventricular zone (SVZ), which provides them with unique signaling cues to control their basic properties and prevent their exhaustion. While the signaling mechanisms that regulate NSC lineage progression are well characterized, the molecular mechanisms that trigger the activation of quiescent NSCs during homeostasis and tissue repair are still unclear. Here, we uncovered that the NSC quiescent state is maintained by Rho-GTPase Cdc42, a downstream target of non-canonical Wnt signaling. Mechanistically, activation of Cdc42 induces expression of molecules involved in stem cell identity and anchorage to the niche. Strikingly, during a demyelination injury, downregulation of non-canonical Wnt-dependent Cdc42 activity is necessary to promote activation and lineage progression of quiescent NSCs, thereby initiating the process of tissue repair.

Suggested Citation

  • Manideep Chavali & Michael Klingener & Alexandros G. Kokkosis & Yury Garkun & Sylwia Felong & Arianna Maffei & Adan Aguirre, 2018. "Non-canonical Wnt signaling regulates neural stem cell quiescence during homeostasis and after demyelination," Nature Communications, Nature, vol. 9(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02440-0
    DOI: 10.1038/s41467-017-02440-0
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    Cited by:

    1. Xing Yang & Haibo Xu & Xu Yang & Hui Wang & Li Zou & Qin Yang & Xiaopeng Qi & Li Li & Hongxia Duan & Xiyun Yan & Nai Yang Fu & Jing Tan & Zongliu Hou & Baowei Jiao, 2024. "Mcam inhibits macrophage-mediated development of mammary gland through non-canonical Wnt signaling," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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