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Network connectivity determines cortical thinning in early Parkinson’s disease progression

Author

Listed:
  • Y. Yau

    (McGill University)

  • Y. Zeighami

    (McGill University)

  • T. E. Baker

    (McGill University
    Rutgers University)

  • K. Larcher

    (McGill University)

  • U. Vainik

    (McGill University
    University of Tartu)

  • M. Dadar

    (McGill University)

  • V. S. Fonov

    (McGill University)

  • P. Hagmann

    (Lausanne University Hospital and University of Lausanne)

  • A. Griffa

    (UMC Utrecht)

  • B. Mišić

    (McGill University)

  • D. L. Collins

    (McGill University)

  • A. Dagher

    (McGill University)

Abstract

Here we test the hypothesis that the neurodegenerative process in Parkinson’s disease (PD) moves stereotypically along neural networks, possibly reflecting the spread of toxic alpha-synuclein molecules. PD patients (n = 105) and matched controls (n = 57) underwent T1-MRI at entry and 1 year later as part of the Parkinson’s Progression Markers Initiative. Over this period, PD patients demonstrate significantly greater cortical thinning than controls in parts of the left occipital and bilateral frontal lobes and right somatomotor-sensory cortex. Cortical thinning is correlated to connectivity (measured functionally or structurally) to a “disease reservoir” evaluated by MRI at baseline. The atrophy pattern in the ventral frontal lobes resembles one described in certain cases of Alzheimer’s disease. Our findings suggest that disease propagation to the cortex in PD follows neuronal connectivity and that disease spread to the cortex may herald the onset of cognitive impairment.

Suggested Citation

  • Y. Yau & Y. Zeighami & T. E. Baker & K. Larcher & U. Vainik & M. Dadar & V. S. Fonov & P. Hagmann & A. Griffa & B. Mišić & D. L. Collins & A. Dagher, 2018. "Network connectivity determines cortical thinning in early Parkinson’s disease progression," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02416-0
    DOI: 10.1038/s41467-017-02416-0
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    Cited by:

    1. Justine Y. Hansen & Golia Shafiei & Jacob W. Vogel & Kelly Smart & Carrie E. Bearden & Martine Hoogman & Barbara Franke & Daan Rooij & Jan Buitelaar & Carrie R. McDonald & Sanjay M. Sisodiya & Lianne , 2022. "Local molecular and global connectomic contributions to cross-disorder cortical abnormalities," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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