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LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription

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  • Cui-Yun Liu

    (Institute for Translational Medicine, College of Medicine, Qingdao University)

  • Yu-Hui Zhang

    (Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College)

  • Rui-Bei Li

    (Northwestern University)

  • Lu-Yu Zhou

    (Institute for Translational Medicine, College of Medicine, Qingdao University)

  • Tao An

    (Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College)

  • Rong-Cheng Zhang

    (Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College)

  • Mei Zhai

    (Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College)

  • Yan Huang

    (Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College)

  • Kao-Wen Yan

    (Institute for Translational Medicine, College of Medicine, Qingdao University)

  • Yan-Han Dong

    (Institute for Translational Medicine, College of Medicine, Qingdao University)

  • Murugavel Ponnusamy

    (Institute for Translational Medicine, College of Medicine, Qingdao University)

  • Chan Shan

    (Institute for Translational Medicine, College of Medicine, Qingdao University)

  • Sheng Xu

    (Institute for Translational Medicine, College of Medicine, Qingdao University)

  • Qi Wang

    (Institute for Translational Medicine, College of Medicine, Qingdao University)

  • Yan-Hui Zhang

    (Institute for Translational Medicine, College of Medicine, Qingdao University)

  • Jian Zhang

    (Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College)

  • Kun Wang

    (Institute for Translational Medicine, College of Medicine, Qingdao University)

Abstract

Increasing evidence suggests that long noncoding RNAs (lncRNAs) play crucial roles in various biological processes. However, little is known about the effects of lncRNAs on autophagy. Here we report that a lncRNA, termed cardiac autophagy inhibitory factor (CAIF), suppresses cardiac autophagy and attenuates myocardial infarction by targeting p53-mediated myocardin transcription. Myocardin expression is upregulated upon H2O2 and ischemia/reperfusion, and knockdown of myocardin inhibits autophagy and attenuates myocardial infarction. p53 regulates cardiomyocytes autophagy and myocardial ischemia/reperfusion injury by regulating myocardin expression. CAIF directly binds to p53 protein and blocks p53-mediated myocardin transcription, which results in the decrease of myocardin expression. Collectively, our data reveal a novel CAIF-p53-myocardin axis as a critical regulator in cardiomyocyte autophagy, which will be potential therapeutic targets in treatment of defective autophagy-associated cardiovascular diseases.

Suggested Citation

  • Cui-Yun Liu & Yu-Hui Zhang & Rui-Bei Li & Lu-Yu Zhou & Tao An & Rong-Cheng Zhang & Mei Zhai & Yan Huang & Kao-Wen Yan & Yan-Han Dong & Murugavel Ponnusamy & Chan Shan & Sheng Xu & Qi Wang & Yan-Hui Zh, 2018. "LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02280-y
    DOI: 10.1038/s41467-017-02280-y
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