IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-017-02244-2.html
   My bibliography  Save this article

Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling

Author

Listed:
  • Josephine Elia

    (Nemours, du Pont Hospital for Children
    Department of Pediatrics Sidney Kimmel Medical College of Thomas Jefferson University
    Department of Psychiatry Sidney Kimmel Medical College of Thomas Jefferson University)

  • Grace Ungal

    (Drexel University College of Medicine)

  • Charlly Kao

    (The Children’s Hospital of Philadelphia)

  • Alexander Ambrosini

    (University of Pennsylvania)

  • Nilsa Jesus-Rosario

    (Department of Psychiatry Sidney Kimmel Medical College of Thomas Jefferson University)

  • Lene Larsen

    (Department of Psychiatry Sidney Kimmel Medical College of Thomas Jefferson University)

  • Rosetta Chiavacci

    (The Children’s Hospital of Philadelphia)

  • Tiancheng Wang

    (The Children’s Hospital of Philadelphia)

  • Christine Kurian

    (Department of Pediatrics Sidney Kimmel Medical College of Thomas Jefferson University)

  • Kanani Titchen

    (Nemours, du Pont Hospital for Children
    Department of Pediatrics Sidney Kimmel Medical College of Thomas Jefferson University)

  • Brian Sykes

    (Nemours, du Pont Hospital for Children
    Department of Pediatrics Sidney Kimmel Medical College of Thomas Jefferson University)

  • Sharon Hwang

    (Nemours, du Pont Hospital for Children
    Department of Pediatrics Sidney Kimmel Medical College of Thomas Jefferson University)

  • Bhumi Kumar

    (Nemours, du Pont Hospital for Children
    Department of Pediatrics Sidney Kimmel Medical College of Thomas Jefferson University)

  • Jacqueline Potts

    (Department of Pediatrics Sidney Kimmel Medical College of Thomas Jefferson University)

  • Joshua Davis

    (Nemours, du Pont Hospital for Children
    Department of Pediatrics Sidney Kimmel Medical College of Thomas Jefferson University)

  • Jeffrey Malatack

    (Nemours, du Pont Hospital for Children)

  • Emma Slattery

    (Department of Pediatrics Sidney Kimmel Medical College of Thomas Jefferson University)

  • Ganesh Moorthy

    (University of Pennsylvania)

  • Athena Zuppa

    (University of Pennsylvania)

  • Andrew Weller

    (Department of Psychiatry Sidney Kimmel Medical College of Thomas Jefferson University)

  • Enda Byrne

    (The Children’s Hospital of Philadelphia)

  • Yun R. Li

    (The Children’s Hospital of Philadelphia
    University of California San Francisco)

  • Walter K. Kraft

    (Department of Pediatrics Sidney Kimmel Medical College of Thomas Jefferson University)

  • Hakon Hakonarson

    (The Children’s Hospital of Philadelphia
    University of Pennsylvania
    The Children’s Hospital of Philadelphia)

Abstract

The glutamatergic neurotransmitter system may play an important role in attention-deficit hyperactivity disorder (ADHD). This 5-week, open-label, single-blind, placebo-controlled study reports the safety, pharmacokinetics and responsiveness of the metabotropic glutamate receptor (mGluR) activator fasoracetam (NFC-1), in 30 adolescents, age 12–17 years with ADHD, harboring mutations in mGluR network genes. Mutation status was double-blinded. A single-dose pharmacokinetic profiling from 50–800 mg was followed by a single-blind placebo at week 1 and subsequent symptom-driven dose advancement up to 400 mg BID for 4 weeks. NFC-1 treatment resulted in significant improvement. Mean Clinical Global Impressions-Improvement (CGI-I) and Severity (CGI-S) scores were, respectively, 3.79 at baseline vs. 2.33 at week 5 (P

Suggested Citation

  • Josephine Elia & Grace Ungal & Charlly Kao & Alexander Ambrosini & Nilsa Jesus-Rosario & Lene Larsen & Rosetta Chiavacci & Tiancheng Wang & Christine Kurian & Kanani Titchen & Brian Sykes & Sharon Hwa, 2018. "Fasoracetam in adolescents with ADHD and glutamatergic gene network variants disrupting mGluR neurotransmitter signaling," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02244-2
    DOI: 10.1038/s41467-017-02244-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-017-02244-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-017-02244-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Hain HS & Connolly JJ & Glessner JT & Elia J & Hakonarson H, 2018. "Toward Individualized Treatments for Neurodevelopmental Disorders Targeting Metabotropic Glutamate Receptor (mGluR) Genes Impacted by Copy Number Variants," Open Access Journal of Neurology & Neurosurgery, Juniper Publishers Inc., vol. 8(2), pages 37-42, August.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-02244-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.