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Injury-activated glial cells promote wound healing of the adult skin in mice

Author

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  • Vadims Parfejevs

    (Institute of Anatomy, University of Zürich
    Faculty of Medicine, University of Latvia)

  • Julien Debbache

    (Institute of Anatomy, University of Zürich)

  • Olga Shakhova

    (University Hospital Zürich)

  • Simon M. Schaefer

    (Institute of Anatomy, University of Zürich)

  • Mareen Glausch

    (Institute of Anatomy, University of Zürich)

  • Michael Wegner

    (Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg)

  • Ueli Suter

    (Institute of Molecular Health Sciences, ETH)

  • Una Riekstina

    (Faculty of Medicine, University of Latvia)

  • Sabine Werner

    (Institute of Molecular Health Sciences, ETH)

  • Lukas Sommer

    (Institute of Anatomy, University of Zürich)

Abstract

Cutaneous wound healing is a complex process that aims to re-establish the original structure of the skin and its functions. Among other disorders, peripheral neuropathies are known to severely impair wound healing capabilities of the skin, revealing the importance of skin innervation for proper repair. Here, we report that peripheral glia are crucially involved in this process. Using a mouse model of wound healing, combined with in vivo fate mapping, we show that injury activates peripheral glia by promoting de-differentiation, cell-cycle re-entry and dissemination of the cells into the wound bed. Moreover, injury-activated glia upregulate the expression of many secreted factors previously associated with wound healing and promote myofibroblast differentiation by paracrine modulation of TGF-β signalling. Accordingly, depletion of these cells impairs epithelial proliferation and wound closure through contraction, while their expansion promotes myofibroblast formation. Thus, injury-activated glia and/or their secretome might have therapeutic potential in human wound healing disorders.

Suggested Citation

  • Vadims Parfejevs & Julien Debbache & Olga Shakhova & Simon M. Schaefer & Mareen Glausch & Michael Wegner & Ueli Suter & Una Riekstina & Sabine Werner & Lukas Sommer, 2018. "Injury-activated glial cells promote wound healing of the adult skin in mice," Nature Communications, Nature, vol. 9(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-017-01488-2
    DOI: 10.1038/s41467-017-01488-2
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