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Midbrain circuit regulation of individual alcohol drinking behaviors in mice

Author

Listed:
  • Barbara Juarez

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Carole Morel

    (Icahn School of Medicine at Mount Sinai)

  • Stacy M. Ku

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Yutong Liu

    (Icahn School of Medicine at Mount Sinai)

  • Hongxing Zhang

    (Icahn School of Medicine at Mount Sinai
    Xuzhou Medical University)

  • Sarah Montgomery

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

  • Hilledna Gregoire

    (Icahn School of Medicine at Mount Sinai)

  • Efrain Ribeiro

    (Icahn School of Medicine at Mount Sinai)

  • Marshall Crumiller

    (Icahn School of Medicine at Mount Sinai)

  • Ciorana Roman-Ortiz

    (Icahn School of Medicine at Mount Sinai)

  • Jessica J. Walsh

    (Icahn School of Medicine at Mount Sinai)

  • Kelcy Jackson

    (Icahn School of Medicine at Mount Sinai)

  • Denise E. Croote

    (Icahn School of Medicine at Mount Sinai)

  • Yingbo Zhu

    (Icahn School of Medicine at Mount Sinai)

  • Song Zhang

    (Icahn School of Medicine at Mount Sinai)

  • Leandro F. Vendruscolo

    (National Institute on Drug Abuse, National Institutes of Health)

  • Scott Edwards

    (Neuroscience Center of Excellence, Louisiana State University Health Sciences Center)

  • Amanda Roberts

    (The Scripps Research Institute)

  • Georgia E. Hodes

    (Icahn School of Medicine at Mount Sinai)

  • Yongke Lu

    (Icahn School of Medicine at Mount Sinai
    College of Public Health, East Tennessee State University)

  • Erin S. Calipari

    (Icahn School of Medicine at Mount Sinai
    Vanderbilt University)

  • Dipesh Chaudhury

    (Icahn School of Medicine at Mount Sinai
    New York University Abu Dhabi (NYUAD), Saadiyat Island Campus)

  • Allyson K. Friedman

    (Icahn School of Medicine at Mount Sinai
    Hunter College, City University of New York)

  • Ming-Hu Han

    (Icahn School of Medicine at Mount Sinai
    Icahn School of Medicine at Mount Sinai)

Abstract

Alcohol-use disorder (AUD) is the most prevalent substance-use disorder worldwide. There is substantial individual variability in alcohol drinking behaviors in the population, the neural circuit mechanisms of which remain elusive. Utilizing in vivo electrophysiological techniques, we find that low alcohol drinking (LAD) mice have dramatically higher ventral tegmental area (VTA) dopamine neuron firing and burst activity. Unexpectedly, VTA dopamine neuron activity in high alcohol drinking (HAD) mice does not differ from alcohol naive mice. Optogenetically enhancing VTA dopamine neuron burst activity in HAD mice decreases alcohol drinking behaviors. Circuit-specific recordings reveal that spontaneous activity of nucleus accumbens-projecting VTA (VTA-NAc) neurons is selectively higher in LAD mice. Specifically activating this projection is sufficient to reduce alcohol consumption in HAD mice. Furthermore, we uncover ionic and cellular mechanisms that suggest unique neuroadaptations between the alcohol drinking groups. Together, these data identify a neural circuit responsible for individual alcohol drinking behaviors.

Suggested Citation

  • Barbara Juarez & Carole Morel & Stacy M. Ku & Yutong Liu & Hongxing Zhang & Sarah Montgomery & Hilledna Gregoire & Efrain Ribeiro & Marshall Crumiller & Ciorana Roman-Ortiz & Jessica J. Walsh & Kelcy , 2017. "Midbrain circuit regulation of individual alcohol drinking behaviors in mice," Nature Communications, Nature, vol. 8(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-02365-8
    DOI: 10.1038/s41467-017-02365-8
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    Cited by:

    1. Carole Morel & Sarah E. Montgomery & Long Li & Romain Durand-de Cuttoli & Emily M. Teichman & Barbara Juarez & Nikos Tzavaras & Stacy M. Ku & Meghan E. Flanigan & Min Cai & Jessica J. Walsh & Scott J., 2022. "Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Malou Dongelmans & Romain Durand-de Cuttoli & Claire Nguyen & Maxime Come & Etienne K. Duranté & Damien Lemoine & Raphaël Brito & Tarek Ahmed Yahia & Sarah Mondoloni & Steve Didienne & Elise Bousseyro, 2021. "Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    3. Yi Han & Lin Ai & Lingzhen Song & Yu Zhou & Dandan Chen & Sha Sha & Ran Ji & Qize Li & Qingyang Bu & Xiangyu Pan & Xiaojing Zhai & Mengqiao Cui & Jiawen Duan & Junxia Yang & Dipesh Chaudhury & Ankang , 2024. "Midbrain glutamatergic circuit mechanism of resilience to socially transferred allodynia in male mice," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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