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Hippocampal-prefrontal theta-gamma coupling during performance of a spatial working memory task

Author

Listed:
  • Makoto Tamura

    (Columbia University
    Mitsubishi Tanabe Pharma Corporation)

  • Timothy J. Spellman

    (Columbia University
    Columbia University)

  • Andrew M. Rosen

    (Columbia University
    Columbia University)

  • Joseph A. Gogos

    (Columbia University
    Columbia University)

  • Joshua A. Gordon

    (Columbia University
    New York State Psychiatry Institute
    National Institute of Mental Health)

Abstract

Cross-frequency coupling supports the organization of brain rhythms and is present during a range of cognitive functions. However, little is known about whether and how long-range cross-frequency coupling across distant brain regions subserves working memory. Here we report that theta–slow gamma coupling between the hippocampus and medial prefrontal cortex (mPFC) is augmented in a genetic mouse model of cognitive dysfunction. This increased cross-frequency coupling is observed specifically when the mice successfully perform a spatial working memory task. In wild-type mice, increasing task difficulty by introducing a long delay or by optogenetically interfering with encoding, also increases theta–gamma coupling during correct trials. Finally, epochs of high hippocampal theta–prefrontal slow gamma coupling are associated with increased synchronization of neurons within the mPFC. These findings suggest that enhancement of theta–slow gamma coupling reflects a compensatory mechanism to maintain spatial working memory performance in the setting of increased difficulty.

Suggested Citation

  • Makoto Tamura & Timothy J. Spellman & Andrew M. Rosen & Joseph A. Gogos & Joshua A. Gordon, 2017. "Hippocampal-prefrontal theta-gamma coupling during performance of a spatial working memory task," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-02108-9
    DOI: 10.1038/s41467-017-02108-9
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    Cited by:

    1. Takahiro Shimizu & Stuart G. Nayar & Matthew Swire & Yi Jiang & Matthew Grist & Malte Kaller & Cassandra Sampaio Baptista & David M. Bannerman & Heidi Johansen-Berg & Katsutoshi Ogasawara & Koujiro To, 2023. "Oligodendrocyte dynamics dictate cognitive performance outcomes of working memory training in mice," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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