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Transformation of the head-direction signal into a spatial code

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  • Adrien Peyrache

    (Neuroscience Institute, School of Medicine
    Montreal Neurological Institute, McGill University)

  • Natalie Schieferstein

    (Neuroscience Institute, School of Medicine
    Department of Biology, Humboldt-Universität zu Berlin)

  • Gyorgy Buzsáki

    (Neuroscience Institute, School of Medicine
    Center for Neuroscience)

Abstract

Animals integrate multiple sensory inputs to successfully navigate in their environments. Head direction (HD), boundary vector, grid and place cells in the entorhinal-hippocampal network form the brain’s navigational system that allows to identify the animal’s current location, but how the functions of these specialized neuron types are acquired remain to be understood. Here we report that activity of HD neurons is influenced by the ambulatory constraints imposed upon the animal by the boundaries of the explored environment, leading to spurious spatial information. However, in the post-subiculum, the main cortical stage of HD signal processing, HD neurons convey true spatial information in the form of border modulated activity through the integration of additional sensory modalities relative to egocentric position, unlike their driving thalamic inputs. These findings demonstrate how the combination of HD and egocentric information can be transduced into a spatial code.

Suggested Citation

  • Adrien Peyrache & Natalie Schieferstein & Gyorgy Buzsáki, 2017. "Transformation of the head-direction signal into a spatial code," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
  • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01908-3
    DOI: 10.1038/s41467-017-01908-3
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    Cited by:

    1. Guillaume Viejo & Thomas Cortier & Adrien Peyrache, 2018. "Brain-state invariant thalamo-cortical coordination revealed by non-linear encoders," PLOS Computational Biology, Public Library of Science, vol. 14(3), pages 1-25, March.

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