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Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA

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Listed:
  • Yuan Tian

    (La Jolla Institute for Allergy and Immunology)

  • Mariana Babor

    (La Jolla Institute for Allergy and Immunology)

  • Jerome Lane

    (La Jolla Institute for Allergy and Immunology)

  • Veronique Schulten

    (La Jolla Institute for Allergy and Immunology)

  • Veena S. Patil

    (La Jolla Institute for Allergy and Immunology)

  • Grégory Seumois

    (La Jolla Institute for Allergy and Immunology)

  • Sandy L. Rosales

    (La Jolla Institute for Allergy and Immunology)

  • Zheng Fu

    (La Jolla Institute for Allergy and Immunology)

  • Gaelle Picarda

    (La Jolla Institute for Allergy and Immunology)

  • Julie Burel

    (La Jolla Institute for Allergy and Immunology)

  • Jose Zapardiel-Gonzalo

    (La Jolla Institute for Allergy and Immunology)

  • Rashika N. Tennekoon

    (La Jolla Institute for Allergy and Immunology
    Genetech Research Institute)

  • Aruna D. Silva

    (La Jolla Institute for Allergy and Immunology
    Genetech Research Institute)

  • Sunil Premawansa

    (Science Faculty, University of Colombo)

  • Gayani Premawansa

    (North Colombo Teaching Hospital)

  • Ananda Wijewickrama

    (National Institute of Infectious Diseases)

  • Jason A. Greenbaum

    (La Jolla Institute for Allergy and Immunology)

  • Pandurangan Vijayanand

    (La Jolla Institute for Allergy and Immunology)

  • Daniela Weiskopf

    (La Jolla Institute for Allergy and Immunology)

  • Alessandro Sette

    (La Jolla Institute for Allergy and Immunology)

  • Bjoern Peters

    (La Jolla Institute for Allergy and Immunology)

Abstract

The expression of CD45RA is generally associated with naive T cells. However, a subset of effector memory T cells re-expresses CD45RA (termed TEMRA) after antigenic stimulation with unknown molecular characteristics and functions. CD4 TEMRA cells have been implicated in protective immunity against pathogens such as dengue virus (DENV). Here we show that not only the frequency but also the phenotype of CD4 TEMRA cells are heterogeneous between individuals. These cells can be subdivided into two major subsets based on the expression of the adhesion G protein-coupled receptor GPR56, and GPR56+ TEMRA cells display a transcriptional and proteomic program with cytotoxic features that is distinct from effector memory T cells. Moreover, GPR56+ TEMRA cells have higher levels of clonal expansion and contain the majority of virus-specific TEMRA cells. Overall, this study reveals the heterogeneity of CD4 TEMRA cells and provides insights into T-cell responses against DENV and other viral pathogens.

Suggested Citation

  • Yuan Tian & Mariana Babor & Jerome Lane & Veronique Schulten & Veena S. Patil & Grégory Seumois & Sandy L. Rosales & Zheng Fu & Gaelle Picarda & Julie Burel & Jose Zapardiel-Gonzalo & Rashika N. Tenne, 2017. "Unique phenotypes and clonal expansions of human CD4 effector memory T cells re-expressing CD45RA," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01728-5
    DOI: 10.1038/s41467-017-01728-5
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    Cited by:

    1. Raquel Furtado & Mahinder Paul & Jinghang Zhang & Joowhan Sung & Paul Karell & Ryung S. Kim & Sophie Caillat-Zucman & Li Liang & Philip Felgner & Andy Bauleni & Syze Gama & Andrea Buchwald & Terrie Ta, 2023. "Cytolytic circumsporozoite-specific memory CD4+ T cell clones are expanded during Plasmodium falciparum infection," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Sarah Cappuyns & Gino Philips & Vincent Vandecaveye & Bram Boeckx & Rogier Schepers & Thomas Van Brussel & Ingrid Arijs & Aurelie Mechels & Ayse Bassez & Francesca Lodi & Joris Jaekers & Halit Topal &, 2023. "PD-1- CD45RA+ effector-memory CD8 T cells and CXCL10+ macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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