IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_s41467-017-01704-z.html
   My bibliography  Save this article

AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor

Author

Listed:
  • Bojun Chen

    (University of Connecticut Health Center)

  • Ping Liu

    (University of Connecticut Health Center)

  • Edward J. Hujber

    (University of Utah
    Howard Hughes Medical Institute, University of Utah)

  • Yan Li

    (University of Connecticut Health Center)

  • Erik M. Jorgensen

    (University of Utah
    Howard Hughes Medical Institute, University of Utah)

  • Zhao-Wen Wang

    (University of Connecticut Health Center)

Abstract

Pituitary tumors are frequently associated with mutations in the AIP gene and are sometimes associated with hypersecretion of growth hormone. It is unclear whether other factors besides an enlarged pituitary contribute to the hypersecretion. In a genetic screen for suppressors of reduced neurotransmitter release, we identified a mutation in Caenorhabditis elegans AIPR-1 (AIP-related-1), which causes profound increases in evoked and spontaneous neurotransmitter release, a high frequency of spontaneous calcium transients in motor neurons and an enlarged readily releasable pool of vesicles. Calcium bursts and hypersecretion are reversed by mutations in the ryanodine receptor but not in the voltage-gated calcium channel, indicating that these phenotypes are caused by a leaky ryanodine receptor. AIPR-1 is physically associated with the ryanodine receptor at synapses. Finally, the phenotypes in aipr-1 mutants can be rescued by presynaptic expression of mouse AIP, demonstrating that a conserved function of AIP proteins is to inhibit calcium release from ryanodine receptors.

Suggested Citation

  • Bojun Chen & Ping Liu & Edward J. Hujber & Yan Li & Erik M. Jorgensen & Zhao-Wen Wang, 2017. "AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor," Nature Communications, Nature, vol. 8(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01704-z
    DOI: 10.1038/s41467-017-01704-z
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-017-01704-z
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-017-01704-z?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Xu Zhan & Chao Chen & Longgang Niu & Xinran Du & Ying Lei & Rui Dan & Zhao-Wen Wang & Ping Liu, 2023. "Locomotion modulates olfactory learning through proprioception in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01704-z. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.