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The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity

Author

Listed:
  • Alexandra Santanach

    (The Barcelona Institute of Science and Technology
    Universitat Pompeu Fabra (UPF))

  • Enrique Blanco

    (The Barcelona Institute of Science and Technology
    Universitat Pompeu Fabra (UPF))

  • Hua Jiang

    (The Rockefeller University)

  • Kelly R. Molloy

    (The Rockefeller University)

  • Miriam Sansó

    (The Barcelona Institute of Science and Technology
    Universitat Pompeu Fabra (UPF))

  • John LaCava

    (The Rockefeller University
    New York University School of Medicine)

  • Lluis Morey

    (The Barcelona Institute of Science and Technology
    Universitat Pompeu Fabra (UPF)
    Department of Human Genetics, University of Miami Miller School of Medicine)

  • Luciano Di Croce

    (The Barcelona Institute of Science and Technology
    Universitat Pompeu Fabra (UPF)
    Pg. Lluis Companys 23)

Abstract

Polycomb group proteins (PcG) are transcriptional repressors that control cell identity and development. In mammals, five different CBX proteins associate with the core Polycomb repressive complex 1 (PRC1). In mouse embryonic stem cells (ESCs), CBX6 and CBX7 are the most highly expressed CBX family members. CBX7 has been recently characterized, but little is known regarding the function of CBX6. Here, we show that CBX6 is essential for ESC identity. Its depletion destabilizes the pluripotency network and triggers differentiation. Mechanistically, we find that CBX6 is physically and functionally associated to both canonical PRC1 (cPRC1) and non-canonical PRC1 (ncPRC1) complexes. Notably, in contrast to CBX7, CBX6 is recruited to chromatin independently of H3K27me3. Taken together, our findings reveal that CBX6 is an essential component of ESC biology that contributes to the structural and functional complexity of the PRC1 complex.

Suggested Citation

  • Alexandra Santanach & Enrique Blanco & Hua Jiang & Kelly R. Molloy & Miriam Sansó & John LaCava & Lluis Morey & Luciano Di Croce, 2017. "The Polycomb group protein CBX6 is an essential regulator of embryonic stem cell identity," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01464-w
    DOI: 10.1038/s41467-017-01464-w
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    Cited by:

    1. David Martino & Nina Kresoje & Nelly Amenyogbe & Rym Ben-Othman & Bing Cai & Mandy Lo & Olubukola Idoko & Oludare A. Odumade & Reza Falsafi & Travis M. Blimkie & Andy An & Casey P. Shannon & Sebastian, 2024. "DNA Methylation signatures underpinning blood neutrophil to lymphocyte ratio during first week of human life," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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