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Polymer mimics of biomacromolecular antifreezes

Author

Listed:
  • Caroline I. Biggs

    (University of Warwick)

  • Trisha L. Bailey

    (University of Warwick)

  • Graham

    (University of Warwick)

  • Christopher Stubbs

    (University of Warwick)

  • Alice Fayter

    (University of Warwick)

  • Matthew I. Gibson

    (University of Warwick
    Warwick Medical School, University of Warwick)

Abstract

Antifreeze proteins from polar fish species are remarkable biomacromolecules which prevent the growth of ice crystals. Ice crystal growth is a major problem in cell/tissue cryopreservation for transplantation, transfusion and basic biomedical research, as well as technological applications such as icing of aircraft wings. This review will introduce the rapidly emerging field of synthetic macromolecular (polymer) mimics of antifreeze proteins. Particular focus is placed on designing polymers which have no structural similarities to antifreeze proteins but reproduce the same macroscopic properties, potentially by different molecular-level mechanisms. The application of these polymers to the cryopreservation of donor cells is also introduced.

Suggested Citation

  • Caroline I. Biggs & Trisha L. Bailey & Graham & Christopher Stubbs & Alice Fayter & Matthew I. Gibson, 2017. "Polymer mimics of biomacromolecular antifreezes," Nature Communications, Nature, vol. 8(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01421-7
    DOI: 10.1038/s41467-017-01421-7
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    Cited by:

    1. Yiming Ma & Jun Zhang & Yunqing Tian & Yihao Fu & Shu Tian & Qingsi Li & Jing Yang & Lei Zhang, 2023. "Zwitterionic microgel preservation platform for circulating tumor cells in whole blood specimen," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Matthew T. Warren & Caroline I. Biggs & Akalabya Bissoyi & Matthew I. Gibson & Gabriele C. Sosso, 2024. "Data-driven discovery of potent small molecule ice recrystallisation inhibitors," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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