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Large-scale suppression of recombination predates genomic rearrangements in Neurospora tetrasperma

Author

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  • Yu Sun

    (Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University)

  • Jesper Svedberg

    (Uppsala University)

  • Markus Hiltunen

    (Uppsala University)

  • Pádraic Corcoran

    (University of Sheffield)

  • Hanna Johannesson

    (Uppsala University)

Abstract

A common feature of eukaryote genomes is large chromosomal regions where recombination is absent or strongly reduced, but the factors that cause this reduction are not well understood. Genomic rearrangements have often been implicated, but they may also be a consequence of recombination suppression rather than a cause. In this study, we generate eight high-quality genomic data sets of the filamentous ascomycete Neurospora tetrasperma, a fungus that lacks recombination over most of its largest chromosome. The genomes surprisingly reveal collinearity of the non-recombining regions and although large inversions are enriched in these regions, we conclude these inversions to be derived and not the cause of the suppression. To our knowledge, this is the first time that non-recombining, genic regions as large as 86% of a full chromosome (or 8 Mbp), are shown to be collinear. These findings are of significant interest for our understanding of the evolution of sex chromosomes and other supergene complexes.

Suggested Citation

  • Yu Sun & Jesper Svedberg & Markus Hiltunen & Pádraic Corcoran & Hanna Johannesson, 2017. "Large-scale suppression of recombination predates genomic rearrangements in Neurospora tetrasperma," Nature Communications, Nature, vol. 8(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01317-6
    DOI: 10.1038/s41467-017-01317-6
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