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RETRACTED ARTICLE: Sulfur availability regulates plant growth via glucose-TOR signaling

Author

Listed:
  • Yihan Dong

    (University of Heidelberg)

  • Marleen Silbermann

    (University of Heidelberg)

  • Anna Speiser

    (University of Heidelberg)

  • Ilaria Forieri

    (University of Heidelberg)

  • Eric Linster

    (University of Heidelberg)

  • Gernot Poschet

    (University of Heidelberg)

  • Arman Allboje Samami

    (University of Heidelberg)

  • Mutsumi Wanatabe

    (Chiba University)

  • Carsten Sticht

    (University of Mannheim)

  • Aurelio A. Teleman

    (German Cancer Research Center (DKFZ))

  • Jean-Marc Deragon

    (Centre National de la Recherche Scientifique, University of Perpignan)

  • Kazuki Saito

    (Chiba University)

  • Rüdiger Hell

    (University of Heidelberg)

  • Markus Wirtz

    (University of Heidelberg)

Abstract

Growth of eukaryotic cells is regulated by the target of rapamycin (TOR). The strongest activator of TOR in metazoa is amino acid availability. The established transducers of amino acid sensing to TOR in metazoa are absent in plants. Hence, a fundamental question is how amino acid sensing is achieved in photo-autotrophic organisms. Here we demonstrate that the plant Arabidopsis does not sense the sulfur-containing amino acid cysteine itself, but its biosynthetic precursors. We identify the kinase GCN2 as a sensor of the carbon/nitrogen precursor availability, whereas limitation of the sulfur precursor is transduced to TOR by downregulation of glucose metabolism. The downregulated TOR activity caused decreased translation, lowered meristematic activity, and elevated autophagy. Our results uncover a plant-specific adaptation of TOR function. In concert with GCN2, TOR allows photo-autotrophic eukaryotes to coordinate the fluxes of carbon, nitrogen, and sulfur for efficient cysteine biosynthesis under varying external nutrient supply.

Suggested Citation

  • Yihan Dong & Marleen Silbermann & Anna Speiser & Ilaria Forieri & Eric Linster & Gernot Poschet & Arman Allboje Samami & Mutsumi Wanatabe & Carsten Sticht & Aurelio A. Teleman & Jean-Marc Deragon & Ka, 2017. "RETRACTED ARTICLE: Sulfur availability regulates plant growth via glucose-TOR signaling," Nature Communications, Nature, vol. 8(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01224-w
    DOI: 10.1038/s41467-017-01224-w
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    Cited by:

    1. Eric Linster & Francy L. Forero Ruiz & Pavlina Miklankova & Thomas Ruppert & Johannes Mueller & Laura Armbruster & Xiaodi Gong & Giovanna Serino & Matthias Mann & Rüdiger Hell & Markus Wirtz, 2022. "Cotranslational N-degron masking by acetylation promotes proteome stability in plants," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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