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Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy

Author

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  • Musarrat Maisha Reza

    (Nanyang Technological University)

  • Nathiya Subramaniyam

    (Brenner Centre for Molecular Medicine)

  • Chu Ming Sim

    (Brenner Centre for Molecular Medicine)

  • Xiaojia Ge

    (Brenner Centre for Molecular Medicine)

  • Durgalakshmi Sathiakumar

    (Brenner Centre for Molecular Medicine)

  • Craig McFarlane

    (Brenner Centre for Molecular Medicine
    James Cook University)

  • Mridula Sharma

    (National University of Singapore)

  • Ravi Kambadur

    (Nanyang Technological University
    Brenner Centre for Molecular Medicine)

Abstract

Exercise induces expression of the myokine irisin, which is known to promote browning of white adipose tissue and has been shown to mediate beneficial effects following exercise. Here we show that irisin induces expression of a number of pro-myogenic and exercise response genes in myotubes. Irisin increases myogenic differentiation and myoblast fusion via activation of IL6 signaling. Injection of irisin in mice induces significant hypertrophy and enhances grip strength of uninjured muscle. Following skeletal muscle injury, irisin injection improves regeneration and induces hypertrophy. The effects of irisin on hypertrophy are due to activation of satellite cells and enhanced protein synthesis. In addition, irisin injection rescues loss of skeletal muscle mass following denervation by enhancing satellite cell activation and reducing protein degradation. These data suggest that irisin functions as a pro-myogenic factor in mice.

Suggested Citation

  • Musarrat Maisha Reza & Nathiya Subramaniyam & Chu Ming Sim & Xiaojia Ge & Durgalakshmi Sathiakumar & Craig McFarlane & Mridula Sharma & Ravi Kambadur, 2017. "Irisin is a pro-myogenic factor that induces skeletal muscle hypertrophy and rescues denervation-induced atrophy," Nature Communications, Nature, vol. 8(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-01131-0
    DOI: 10.1038/s41467-017-01131-0
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    Cited by:

    1. Flavia A. Graca & Mamta Rai & Liam C. Hunt & Anna Stephan & Yong-Dong Wang & Brittney Gordon & Ruishan Wang & Giovanni Quarato & Beisi Xu & Yiping Fan & Myriam Labelle & Fabio Demontis, 2022. "The myokine Fibcd1 is an endogenous determinant of myofiber size and mitigates cancer-induced myofiber atrophy," Nature Communications, Nature, vol. 13(1), pages 1-22, December.

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