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Neutrophil-inspired propulsion in a combined acoustic and magnetic field

Author

Listed:
  • Daniel Ahmed

    (Institute of Robotics and Intelligent Systems, ETH Zurich)

  • Thierry Baasch

    (Institute of Mechanical Systems, ETH Zurich)

  • Nicolas Blondel

    (Institute of Robotics and Intelligent Systems, ETH Zurich)

  • Nino Läubli

    (Institute of Robotics and Intelligent Systems, ETH Zurich)

  • Jürg Dual

    (Institute of Mechanical Systems, ETH Zurich)

  • Bradley J. Nelson

    (Institute of Robotics and Intelligent Systems, ETH Zurich)

Abstract

Systems capable of precise motion in the vasculature can offer exciting possibilities for applications in targeted therapeutics and non-invasive surgery. So far, the majority of the work analysed propulsion in a two-dimensional setting with limited controllability near boundaries. Here we show bio-inspired rolling motion by introducing superparamagnetic particles in magnetic and acoustic fields, inspired by a neutrophil rolling on a wall. The particles self-assemble due to dipole–dipole interaction in the presence of a rotating magnetic field. The aggregate migrates towards the wall of the channel due to the radiation force of an acoustic field. By combining both fields, we achieved a rolling-type motion along the boundaries. The use of both acoustic and magnetic fields has matured in clinical settings. The combination of both fields is capable of overcoming the limitations encountered by single actuation techniques. We believe our method will have far-reaching implications in targeted therapeutics.

Suggested Citation

  • Daniel Ahmed & Thierry Baasch & Nicolas Blondel & Nino Läubli & Jürg Dual & Bradley J. Nelson, 2017. "Neutrophil-inspired propulsion in a combined acoustic and magnetic field," Nature Communications, Nature, vol. 8(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00845-5
    DOI: 10.1038/s41467-017-00845-5
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    Cited by:

    1. Gaurav Gardi & Steven Ceron & Wendong Wang & Kirstin Petersen & Metin Sitti, 2022. "Microrobot collectives with reconfigurable morphologies, behaviors, and functions," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Zhiyuan Zhang & Alexander Sukhov & Jens Harting & Paolo Malgaretti & Daniel Ahmed, 2022. "Rolling microswarms along acoustic virtual walls," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    3. Cornel Dillinger & Nitesh Nama & Daniel Ahmed, 2021. "Ultrasound-activated ciliary bands for microrobotic systems inspired by starfish," Nature Communications, Nature, vol. 12(1), pages 1-11, December.

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