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Targeted gadofullerene for sensitive magnetic resonance imaging and risk-stratification of breast cancer

Author

Listed:
  • Zheng Han

    (Case Western Reserve University)

  • Xiaohui Wu

    (Case Western Reserve University)

  • Sarah Roelle

    (Case Western Reserve University)

  • Chuheng Chen

    (Case Western Reserve University)

  • William P. Schiemann

    (Case Western Reserve University)

  • Zheng-Rong Lu

    (Case Western Reserve University
    Case Western Reserve University)

Abstract

Molecular imaging of cancer biomarkers is critical for non-invasive accurate cancer detection and risk-stratification in precision healthcare. A peptide-targeted tri-gadolinium nitride metallofullerene, ZD2-Gd3N@C80, is synthesised for sensitive molecular magnetic resonance imaging of extradomain-B fibronectin in aggressive tumours. ZD2-Gd3N@C80 has superior r 1 and r 2 relaxivities of 223.8 and 344.7 mM−1 s−1 (1.5 T), respectively. It generates prominent contrast enhancement in aggressive MDA-MB-231 triple negative breast cancer in mice at a low dose (1.7 µmol kg−1, 1 T), but not in oestrogen receptor-positive MCF-7 tumours. Strong tumour contrast enhancement is consistently observed in other triple negative breast cancer models, but not in low-risk slow-growing tumours. The dose of the contrast agent for effective molecular MRI is only slightly higher than that of ZD2-Cy5.5 (0.5 µmol kg−1) in fluorescence imaging. These results demonstrate that high-sensitivity molecular magnetic resonance imaging with ZD2-Gd3N@C80 may provide accurate detection and risk-stratification of high-risk tumours for precision healthcare of breast cancer.

Suggested Citation

  • Zheng Han & Xiaohui Wu & Sarah Roelle & Chuheng Chen & William P. Schiemann & Zheng-Rong Lu, 2017. "Targeted gadofullerene for sensitive magnetic resonance imaging and risk-stratification of breast cancer," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00741-y
    DOI: 10.1038/s41467-017-00741-y
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    Cited by:

    1. Hongwei Lu & An Chen & Xindan Zhang & Zixiang Wei & Rong Cao & Yi Zhu & Jingxiong Lu & Zhongling Wang & Leilei Tian, 2022. "A pH-responsive T1-T2 dual-modal MRI contrast agent for cancer imaging," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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