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A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage

Author

Listed:
  • Chao Shan

    (University of Texas Medical Branch)

  • Antonio E. Muruato

    (University of Texas Medical Branch)

  • Brett W. Jagger

    (Washington University School of Medicine)

  • Justin Richner

    (Washington University School of Medicine)

  • Bruno T. D. Nunes

    (University of Texas Medical Branch
    Ministry of Health)

  • Daniele B. A. Medeiros

    (University of Texas Medical Branch
    Ministry of Health)

  • Xuping Xie

    (University of Texas Medical Branch)

  • Jannyce G. C. Nunes

    (University of Texas Medical Branch
    Ministry of Health)

  • Kaitlyn M. Morabito

    (National Institutes of Health)

  • Wing-Pui Kong

    (National Institutes of Health)

  • Theodore C. Pierson

    (National Institutes of Health)

  • Alan D. Barrett

    (University of Texas Medical Branch
    University of Texas Medical Branch
    University of Texas Medical Branch
    University of Texas Medical Branch)

  • Scott C. Weaver

    (University of Texas Medical Branch
    University of Texas Medical Branch
    University of Texas Medical Branch
    University of Texas Medical Branch)

  • Shannan L. Rossi

    (University of Texas Medical Branch
    University of Texas Medical Branch
    University of Texas Medical Branch)

  • Pedro F. C. Vasconcelos

    (Ministry of Health
    Pará State University)

  • Barney S. Graham

    (National Institutes of Health)

  • Michael S. Diamond

    (Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine
    Washington University School of Medicine)

  • Pei-Yong Shi

    (University of Texas Medical Branch
    University of Texas Medical Branch
    University of Texas Medical Branch
    Pará State University)

Abstract

Zika virus infection during pregnancy can cause congenital abnormities or fetal demise. The persistence of Zika virus in the male reproductive system poses a risk of sexual transmission. Here we demonstrate that live-attenuated Zika virus vaccine candidates containing deletions in the 3′ untranslated region of the Zika virus genome (ZIKV-3′UTR-LAV) prevent viral transmission during pregnancy and testis damage in mice, as well as infection of nonhuman primates. After a single-dose vaccination, pregnant mice challenged with Zika virus at embryonic day 6 and evaluated at embryonic day 13 show markedly diminished levels of viral RNA in maternal, placental, and fetal tissues. Vaccinated male mice challenged with Zika virus were protected against testis infection, injury, and oligospermia. A single immunization of rhesus macaques elicited a rapid and robust antibody response, conferring complete protection upon challenge. Furthermore, the ZIKV-3′UTR-LAV vaccine candidates have a desirable safety profile. These results suggest that further development of ZIKV-3′UTR-LAV is warranted for humans.

Suggested Citation

  • Chao Shan & Antonio E. Muruato & Brett W. Jagger & Justin Richner & Bruno T. D. Nunes & Daniele B. A. Medeiros & Xuping Xie & Jannyce G. C. Nunes & Kaitlyn M. Morabito & Wing-Pui Kong & Theodore C. Pi, 2017. "A single-dose live-attenuated vaccine prevents Zika virus pregnancy transmission and testis damage," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00737-8
    DOI: 10.1038/s41467-017-00737-8
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    Cited by:

    1. Youssouf Sereme & Cécile Schrimp & Helène Faury & Maeva Agapoff & Esther Lefebvre-Wloszczowski & Yunhua Chang Marchand & Elisabeth Ageron-Ardila & Emilie Panafieu & Frank Blec & Mathieu Coureuil & Eri, 2024. "A live attenuated vaccine to prevent severe neonatal Escherichia coli K1 infections," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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