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DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1

Author

Listed:
  • Jing Ting Wong

    (Ngee Ann Polytechnic)

  • Farzanah Akhbar

    (Temasek Polytechnic)

  • Amanda Yunn Ee Ng

    (1 Research Link National University of Singapore)

  • Mandy Li-Ian Tay

    (1 Research Link National University of Singapore)

  • Gladys Jing En Loi

    (National University of Singapore)

  • Jun Wei Pek

    (1 Research Link National University of Singapore)

Abstract

Stable intronic sequence RNAs (sisRNAs) are by-products of splicing and regulate gene expression. How sisRNAs are regulated is unclear. Here we report that a double-stranded RNA binding protein, Disco-interacting protein 1 (DIP1) regulates sisRNAs in Drosophila. DIP1 negatively regulates the abundance of sisR-1 and INE-1 sisRNAs. Fine-tuning of sisR-1 by DIP1 is important to maintain female germline stem cell homeostasis by modulating germline stem cell differentiation and niche adhesion. Drosophila DIP1 localizes to a nuclear body (satellite body) and associates with the fourth chromosome, which contains a very high density of INE-1 transposable element sequences that are processed into sisRNAs. DIP1 presumably acts outside the satellite bodies to regulate sisR-1, which is not on the fourth chromosome. Thus, our study identifies DIP1 as a sisRNA regulatory protein that controls germline stem cell self-renewal in Drosophila.

Suggested Citation

  • Jing Ting Wong & Farzanah Akhbar & Amanda Yunn Ee Ng & Mandy Li-Ian Tay & Gladys Jing En Loi & Jun Wei Pek, 2017. "DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1," Nature Communications, Nature, vol. 8(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00684-4
    DOI: 10.1038/s41467-017-00684-4
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    Cited by:

    1. Annabel Qi En Ng & Seow Neng Chan & Jun Wei Pek, 2024. "Nutrient-dependent regulation of a stable intron modulates germline mitochondrial quality control," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    2. Chengyun Wu & Xingsong Wang & Yan Li & Weibo Zhen & Chunfei Wang & Xiaoqing Wang & Zhouli Xie & Xiumei Xu & Siyi Guo & José Ramón Botella & Binglian Zheng & Wei Wang & Chun-Peng Song & Zhubing Hu, 2024. "Sequestration of DBR1 to stress granules promotes lariat intronic RNAs accumulation for heat-stress tolerance," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    3. Shurong Liu & Junhong Huang & Jie Zhou & Siyan Chen & Wujian Zheng & Chang Liu & Qiao Lin & Ping Zhang & Di Wu & Simeng He & Jiayi Ye & Shun Liu & Keren Zhou & Bin Li & Lianghu Qu & Jianhua Yang, 2024. "NAP-seq reveals multiple classes of structured noncoding RNAs with regulatory functions," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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