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A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction

Author

Listed:
  • Michael R. Bowl

    (Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre))

  • Michelle M. Simon

    (Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre))

  • Neil J. Ingham

    (King’s College London
    Wellcome Trust Genome Campus)

  • Simon Greenaway

    (Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre))

  • Luis Santos

    (Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre))

  • Heather Cater

    (Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre))

  • Sarah Taylor

    (Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre))

  • Jeremy Mason

    (Wellcome Trust Genome Campus)

  • Natalja Kurbatova

    (Wellcome Trust Genome Campus)

  • Selina Pearson

    (Wellcome Trust Genome Campus)

  • Lynette R. Bower

    (University of California)

  • Dave A. Clary

    (University of California)

  • Hamid Meziane

    (Institut Clinique de la Souris (ICS))

  • Patrick Reilly

    (Institut Clinique de la Souris (ICS))

  • Osamu Minowa

    (RIKEN BioResource Center)

  • Lois Kelsey

    (The Centre for Phenogenomics
    The Hospital for Sick Children
    Canada and Mount Sinai Hospital)

  • Glauco P. Tocchini-Valentini

    (Institute of Cell Biology and Neurobiology)

  • Xiang Gao

    (Nanjing University)

  • Allan Bradley

    (Wellcome Trust Genome Campus)

  • William C. Skarnes

    (Wellcome Trust Genome Campus)

  • Mark Moore

    (IMPC)

  • Arthur L. Beaudet

    (Baylor College of Medicine)

  • Monica J. Justice

    (The Centre for Phenogenomics
    The Hospital for Sick Children
    Canada and Mount Sinai Hospital
    Baylor College of Medicine)

  • John Seavitt

    (Baylor College of Medicine)

  • Mary E. Dickinson

    (Baylor College of Medicine)

  • Wolfgang Wurst

    (Helmholtz Zentrum München, German Research Center for Environmental Health GmbH)

  • Martin Hrabe Angelis

    (German Research Center for Environmental Health GmbH)

  • Yann Herault

    (Institut Clinique de la Souris (ICS)
    Université de Strasbourg
    Centre National de la Recherche Scientifique, UMR7104
    Institut National de la Santé et de la Recherche Médicale)

  • Shigeharu Wakana

    (RIKEN BioResource Center)

  • Lauryl M. J. Nutter

    (The Centre for Phenogenomics
    The Hospital for Sick Children
    Canada and Mount Sinai Hospital)

  • Ann M. Flenniken

    (The Centre for Phenogenomics
    The Hospital for Sick Children
    Canada and Mount Sinai Hospital)

  • Colin McKerlie

    (The Centre for Phenogenomics
    The Hospital for Sick Children
    Canada and Mount Sinai Hospital)

  • Stephen A. Murray

    (The Jackson Laboratory)

  • Karen L. Svenson

    (The Jackson Laboratory)

  • Robert E. Braun

    (The Jackson Laboratory)

  • David B. West

    (Childrens’ Hospital Oakland Research Institute)

  • K. C. Kent Lloyd

    (University of California)

  • David J. Adams

    (Wellcome Trust Genome Campus)

  • Jacqui White

    (Wellcome Trust Genome Campus)

  • Natasha Karp

    (Wellcome Trust Genome Campus)

  • Paul Flicek

    (Wellcome Trust Genome Campus)

  • Damian Smedley

    (Queen Mary University of London)

  • Terrence F. Meehan

    (Wellcome Trust Genome Campus)

  • Helen E. Parkinson

    (Wellcome Trust Genome Campus)

  • Lydia M. Teboul

    (Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre))

  • Sara Wells

    (Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre))

  • Karen P. Steel

    (King’s College London
    Wellcome Trust Genome Campus)

  • Ann-Marie Mallon

    (Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre))

  • Steve D. M. Brown

    (Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre))

Abstract

The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In humans, over 150 non-syndromic loci have been identified, and there are more than 400 human genetic syndromes with a hearing loss component. Over 100 non-syndromic hearing loss genes have been identified in mouse and human, but we remain ignorant of the full extent of the genetic landscape involved in auditory dysfunction. As part of the International Mouse Phenotyping Consortium, we undertook a hearing loss screen in a cohort of 3006 mouse knockout strains. In total, we identify 67 candidate hearing loss genes. We detect known hearing loss genes, but the vast majority, 52, of the candidate genes were novel. Our analysis reveals a large and unexplored genetic landscape involved with auditory function.

Suggested Citation

  • Michael R. Bowl & Michelle M. Simon & Neil J. Ingham & Simon Greenaway & Luis Santos & Heather Cater & Sarah Taylor & Jeremy Mason & Natalja Kurbatova & Selina Pearson & Lynette R. Bower & Dave A. Cla, 2017. "A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00595-4
    DOI: 10.1038/s41467-017-00595-4
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    Cited by:

    1. Joel T. Rämö & Tuomo Kiiskinen & Richard Seist & Kristi Krebs & Masahiro Kanai & Juha Karjalainen & Mitja Kurki & Eija Hämäläinen & Paavo Häppölä & Aki S. Havulinna & Heidi Hautakangas & Reedik Mägi &, 2023. "Genome-wide screen of otosclerosis in population biobanks: 27 loci and shared associations with skeletal structure," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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