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Nanopore extended field-effect transistor for selective single-molecule biosensing

Author

Listed:
  • Ren Ren

    (Imperial College London
    Imperial College London)

  • Yanjun Zhang

    (Imperial College London
    Tianjin Medical University General Hospital)

  • Binoy Paulose Nadappuram

    (Imperial College London)

  • Bernice Akpinar

    (Imperial College London)

  • David Klenerman

    (University of Cambridge)

  • Aleksandar P. Ivanov

    (Imperial College London)

  • Joshua B. Edel

    (Imperial College London)

  • Yuri Korchev

    (Imperial College London
    National University of Science & Technology MISIS)

Abstract

There has been a significant drive to deliver nanotechnological solutions to biosensing, yet there remains an unmet need in the development of biosensors that are affordable, integrated, fast, capable of multiplexed detection, and offer high selectivity for trace analyte detection in biological fluids. Herein, some of these challenges are addressed by designing a new class of nanoscale sensors dubbed nanopore extended field-effect transistor (nexFET) that combine the advantages of nanopore single-molecule sensing, field-effect transistors, and recognition chemistry. We report on a polypyrrole functionalized nexFET, with controllable gate voltage that can be used to switch on/off, and slow down single-molecule DNA transport through a nanopore. This strategy enables higher molecular throughput, enhanced signal-to-noise, and even heightened selectivity via functionalization with an embedded receptor. This is shown for selective sensing of an anti-insulin antibody in the presence of its IgG isotype.

Suggested Citation

  • Ren Ren & Yanjun Zhang & Binoy Paulose Nadappuram & Bernice Akpinar & David Klenerman & Aleksandar P. Ivanov & Joshua B. Edel & Yuri Korchev, 2017. "Nanopore extended field-effect transistor for selective single-molecule biosensing," Nature Communications, Nature, vol. 8(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00549-w
    DOI: 10.1038/s41467-017-00549-w
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    Cited by:

    1. Ren Ren & Shenglin Cai & Xiaona Fang & Xiaoyi Wang & Zheng Zhang & Micol Damiani & Charlotte Hudlerova & Annachiara Rosa & Joshua Hope & Nicola J. Cook & Peter Gorelkin & Alexander Erofeev & Pavel Nov, 2023. "Multiplexed detection of viral antigen and RNA using nanopore sensing and encoded molecular probes," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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