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A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity

Author

Listed:
  • Victoria E. Ruiz

    (New York University School of Medicine (NYUSM))

  • Thomas Battaglia

    (New York University School of Medicine (NYUSM))

  • Zachary D. Kurtz

    (New York University School of Medicine (NYUSM))

  • Luc Bijnens

    (Janssen R&D, Janssen Pharmaceutical Companies of J&J)

  • Amy Ou

    (New York University School of Medicine (NYUSM))

  • Isak Engstrand

    (Karolinska Institutet)

  • Xuhui Zheng

    (New York University School of Medicine (NYUSM))

  • Tadasu Iizumi

    (New York University School of Medicine (NYUSM))

  • Briana J. Mullins

    (New York University School of Medicine (NYUSM))

  • Christian L. Müller

    (Center for Computational Biology, Flatiron Institute, Simons Foundation)

  • Ken Cadwell

    (Kimmel Center for Biology and Medicine at the Skirball Institute, NYUSM)

  • Richard Bonneau

    (Center for Computational Biology, Flatiron Institute, Simons Foundation
    Center for Genomics and Systems Biology, NYU
    Courant Institute of Mathematical Sciences, NYU)

  • Guillermo I. Perez-Perez

    (New York University School of Medicine (NYUSM))

  • Martin J. Blaser

    (New York University School of Medicine (NYUSM)
    New York Harbor Department of Veterans Affairs Medical Center)

Abstract

Broad-spectrum antibiotics are frequently prescribed to children. Early childhood represents a dynamic period for the intestinal microbial ecosystem, which is readily shaped by environmental cues; antibiotic-induced disruption of this sensitive community may have long-lasting host consequences. Here we demonstrate that a single pulsed macrolide antibiotic treatment (PAT) course early in life is sufficient to lead to durable alterations to the murine intestinal microbiota, ileal gene expression, specific intestinal T-cell populations, and secretory IgA expression. A PAT-perturbed microbial community is necessary for host effects and sufficient to transfer delayed secretory IgA expression. Additionally, early-life antibiotic exposure has lasting and transferable effects on microbial community network topology. Our results indicate that a single early-life macrolide course can alter the microbiota and modulate host immune phenotypes that persist long after exposure has ceased.

Suggested Citation

  • Victoria E. Ruiz & Thomas Battaglia & Zachary D. Kurtz & Luc Bijnens & Amy Ou & Isak Engstrand & Xuhui Zheng & Tadasu Iizumi & Briana J. Mullins & Christian L. Müller & Ken Cadwell & Richard Bonneau &, 2017. "A single early-in-life macrolide course has lasting effects on murine microbial network topology and immunity," Nature Communications, Nature, vol. 8(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00531-6
    DOI: 10.1038/s41467-017-00531-6
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    Cited by:

    1. Wen-Long Sun & Sha Hua & Xin-Yu Li & Liang Shen & Hao Wu & Hong-Fang Ji, 2023. "Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Oliver Aasmets & Kertu Liis Krigul & Kreete Lüll & Andres Metspalu & Elin Org, 2022. "Gut metagenome associations with extensive digital health data in a volunteer-based Estonian microbiome cohort," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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