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Complete fusion of a transposon and herpesvirus created the Teratorn mobile element in medaka fish

Author

Listed:
  • Yusuke Inoue

    (The University of Tokyo)

  • Tomonori Saga

    (The University of Tokyo)

  • Takumi Aikawa

    (The University of Tokyo)

  • Masahiko Kumagai

    (The University of Tokyo)

  • Atsuko Shimada

    (The University of Tokyo)

  • Yasushi Kawaguchi

    (The University of Tokyo)

  • Kiyoshi Naruse

    (National Institute for Basic Biology)

  • Shinichi Morishita

    (The University of Tokyo)

  • Akihiko Koga

    (Kyoto University)

  • Hiroyuki Takeda

    (The University of Tokyo)

Abstract

Mobile genetic elements (e.g., transposable elements and viruses) display significant diversity with various life cycles, but how novel elements emerge remains obscure. Here, we report a giant (180-kb long) transposon, Teratorn, originally identified in the genome of medaka, Oryzias latipes. Teratorn belongs to the piggyBac superfamily and retains the transposition activity. Remarkably, Teratorn is largely derived from a herpesvirus of the Alloherpesviridae family that could infect fish and amphibians. Genomic survey of Teratorn-like elements reveals that some of them exist as a fused form between piggyBac transposon and herpesvirus genome in teleosts, implying the generality of transposon-herpesvirus fusion. We propose that Teratorn was created by a unique fusion of DNA transposon and herpesvirus, leading to life cycle shift. Our study supports the idea that recombination is the key event in generation of novel mobile genetic elements.

Suggested Citation

  • Yusuke Inoue & Tomonori Saga & Takumi Aikawa & Masahiko Kumagai & Atsuko Shimada & Yasushi Kawaguchi & Kiyoshi Naruse & Shinichi Morishita & Akihiko Koga & Hiroyuki Takeda, 2017. "Complete fusion of a transposon and herpesvirus created the Teratorn mobile element in medaka fish," Nature Communications, Nature, vol. 8(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00527-2
    DOI: 10.1038/s41467-017-00527-2
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    Cited by:

    1. Hai-Jian Huang & Yi-Yuan Li & Zhuang-Xin Ye & Li-Li Li & Qing-Ling Hu & Yu-Juan He & Yu-Hua Qi & Yan Zhang & Ting Li & Gang Lu & Qian-Zhuo Mao & Ji-Chong Zhuo & Jia-Bao Lu & Zhong-Tian Xu & Zong-Tao S, 2023. "Co-option of a non-retroviral endogenous viral element in planthoppers," Nature Communications, Nature, vol. 14(1), pages 1-19, December.

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