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CLEC5A is a critical receptor in innate immunity against Listeria infection

Author

Listed:
  • Szu-Ting Chen

    (National Yang-Ming University
    National Yang-Ming University
    Taipei Medical University)

  • Fei-Ju Li

    (National Yang-Ming University
    Academia Sinica)

  • Tzy-yun Hsu

    (Academia Sinica)

  • Shu-Mei Liang

    (Academia Sinica
    Academia Sinica)

  • Yi-Chen Yeh

    (Taipei Veterans General Hospital)

  • Wen-Yu Liao

    (Academia Sinica)

  • Teh-Ying Chou

    (National Yang-Ming University
    Taipei Veterans General Hospital)

  • Nien-Jun Chen

    (National Yang-Ming University
    National Yang-Ming University)

  • Michael Hsiao

    (Academia Sinica)

  • Wen-Bin Yang

    (Academia Sinica)

  • Shie-Liang Hsieh

    (National Yang-Ming University
    Academia Sinica
    Taipei Veterans General Hospital
    Taipei Medical University)

Abstract

The C-type lectin member 5A (CLEC5A) is a pattern recognition receptor for members of the Flavivirus family and has critical functions in response to dengue virus and Japanese encephalitis virus. Here we show that CLEC5A is involved in neutrophil extracellular trap formation and the production of reactive oxygen species and proinflammatory cytokines in response to Listeria monocytogenes. Inoculation of Clec5a −/− mice with L. monocytogenes causes rapid bacterial spreading, increased bacterial loads in the blood and liver, and severe liver necrosis. In these mice, IL-1β, IL-17A, and TNF expression is inhibited, CCL2 is induced, and large numbers of CD11b+Ly6ChiCCR2hiCX3CR1low inflammatory monocytes infiltrate the liver. By day 5 of infection, these mice also have fewer IL-17A+ γδ T cells, severe liver necrosis and a higher chance of fatality. Thus, CLEC5A has a pivotal function in the activation of multiple aspects of innate immunity against bacterial invasion.

Suggested Citation

  • Szu-Ting Chen & Fei-Ju Li & Tzy-yun Hsu & Shu-Mei Liang & Yi-Chen Yeh & Wen-Yu Liao & Teh-Ying Chou & Nien-Jun Chen & Michael Hsiao & Wen-Bin Yang & Shie-Liang Hsieh, 2017. "CLEC5A is a critical receptor in innate immunity against Listeria infection," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00356-3
    DOI: 10.1038/s41467-017-00356-3
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    Cited by:

    1. Fan Li & Hui Wang & Yan-Qi Li & Yebo Gu & Xin-Ming Jia, 2023. "C-type lectin receptor 2d forms homodimers and heterodimers with TLR2 to negatively regulate IRF5-mediated antifungal immunity," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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