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Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility

Author

Listed:
  • Amit Sud

    (The Institute of Cancer Research)

  • Hauke Thomsen

    (German Cancer Research Centre)

  • Philip J. Law

    (The Institute of Cancer Research)

  • Asta Försti

    (German Cancer Research Centre
    Lund University)

  • Miguel Inacio da Silva Filho

    (German Cancer Research Centre)

  • Amy Holroyd

    (The Institute of Cancer Research)

  • Peter Broderick

    (The Institute of Cancer Research)

  • Giulia Orlando

    (The Institute of Cancer Research)

  • Oleg Lenive

    (The Institute of Cancer Research)

  • Lauren Wright

    (The Institute of Cancer Research)

  • Rosie Cooke

    (The Institute of Cancer Research)

  • Douglas Easton

    (University of Cambridge
    University of Cambridge)

  • Paul Pharoah

    (University of Cambridge
    University of Cambridge)

  • Alison Dunning

    (University of Cambridge)

  • Julian Peto

    (London School of Hygiene and Tropical Medicine)

  • Federico Canzian

    (Genomic Epidemiology Group, German Cancer Research Center (DKFZ))

  • Rosalind Eeles

    (The Institute of Cancer Research
    Royal Marsden NHS Foundation Trust)

  • ZSofia Kote-Jarai

    (The Institute of Cancer Research)

  • Kenneth Muir

    (University of Manchester
    Warwick Medical School, Warwick University)

  • Nora Pashayan

    (University of Cambridge
    University College London)

  • Per Hoffmann

    (University of Basel
    University of Bonn)

  • Markus M. Nöthen

    (University of Bonn
    University of Bonn)

  • Karl-Heinz Jöckel

    (University of Duisburg–Essen)

  • Elke Pogge von Strandmann

    (University Hospital of Cologne)

  • Tracy Lightfoot

    (University of York)

  • Eleanor Kane

    (University of York)

  • Eve Roman

    (University of York)

  • Annette Lake

    (MRC University of Glasgow Centre for Virus Research)

  • Dorothy Montgomery

    (MRC University of Glasgow Centre for Virus Research)

  • Ruth F. Jarrett

    (MRC University of Glasgow Centre for Virus Research)

  • Anthony J. Swerdlow

    (The Institute of Cancer Research
    The Institute of Cancer Research)

  • Andreas Engert

    (University Hospital of Cologne)

  • Nick Orr

    (The Institute of Cancer Research)

  • Kari Hemminki

    (German Cancer Research Centre
    Lund University)

  • Richard S. Houlston

    (The Institute of Cancer Research
    The Institute of Cancer Research)

Abstract

Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 × 10−8) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10−17), 6q23.3 (rs6928977, P = 4.62 × 10−11), 10p14 (rs3781093, P = 9.49 × 10−13), 13q34 (rs112998813, P = 4.58 × 10−8) and 16p13.13 (rs34972832, P = 2.12 × 10−8). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response.

Suggested Citation

  • Amit Sud & Hauke Thomsen & Philip J. Law & Asta Försti & Miguel Inacio da Silva Filho & Amy Holroyd & Peter Broderick & Giulia Orlando & Oleg Lenive & Lauren Wright & Rosie Cooke & Douglas Easton & Pa, 2017. "Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00320-1
    DOI: 10.1038/s41467-017-00320-1
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    Cited by:

    1. Wei-Yu Lin & Sarah E. Fordham & Eric Hungate & Nicola J. Sunter & Claire Elstob & Yaobo Xu & Catherine Park & Anne Quante & Konstantin Strauch & Christian Gieger & Andrew Skol & Thahira Rahman & Lara , 2021. "Genome-wide association study identifies susceptibility loci for acute myeloid leukemia," Nature Communications, Nature, vol. 12(1), pages 1-10, December.

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