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Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections

Author

Listed:
  • Chao Tian

    (23andMe)

  • Bethann S. Hromatka

    (23andMe)

  • Amy K. Kiefer

    (23andMe)

  • Nicholas Eriksson

    (23andMe)

  • Suzanne M. Noble

    (UCSF
    UCSF)

  • Joyce Y. Tung

    (23andMe)

  • David A. Hinds

    (23andMe)

Abstract

Infectious diseases have a profound impact on our health and many studies suggest that host genetics play a major role in the pathogenesis of most of them. We perform 23 genome-wide association studies for common infections and infection-associated procedures, including chickenpox, shingles, cold sores, mononucleosis, mumps, hepatitis B, plantar warts, positive tuberculosis test results, strep throat, scarlet fever, pneumonia, bacterial meningitis, yeast infections, urinary tract infections, tonsillectomy, childhood ear infections, myringotomy, measles, hepatitis A, rheumatic fever, common colds, rubella and chronic sinus infection, in over 200,000 individuals of European ancestry. We detect 59 genome-wide significant (P

Suggested Citation

  • Chao Tian & Bethann S. Hromatka & Amy K. Kiefer & Nicholas Eriksson & Suzanne M. Noble & Joyce Y. Tung & David A. Hinds, 2017. "Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00257-5
    DOI: 10.1038/s41467-017-00257-5
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    Cited by:

    1. William R. Reay & Michael P. Geaghan & Murray J. Cairns, 2022. "The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Satu Strausz & Erik Abner & Grace Blacker & Sarah Galloway & Paige Hansen & Qingying Feng & Brandon T. Lee & Samuel E. Jones & Hele Haapaniemi & Sten Raak & George Ronald Nahass & Erin Sanders & Pille, 2024. "SCGB1D2 inhibits growth of Borrelia burgdorferi and affects susceptibility to Lyme disease," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    3. Irene V van Blokland & Pauline Lanting & Anil P S Ori & Judith M Vonk & Robert C A Warmerdam & Johanna C Herkert & Floranne Boulogne & Annique Claringbould & Esteban A Lopera-Maya & Meike Bartels & Jo, 2021. "Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility," PLOS ONE, Public Library of Science, vol. 16(8), pages 1-18, August.
    4. Chirag Krishna & Joshua Chiou & Saori Sakaue & Joyce B. Kang & Stephen M. Christensen & Isac Lee & Melis Atalar Aksit & Hye In Kim & David Schack & Soumya Raychaudhuri & Daniel Ziemek & Xinli Hu, 2024. "The influence of HLA genetic variation on plasma protein expression," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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