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Oropharyngeal mucosal transmission of Zika virus in rhesus macaques

Author

Listed:
  • Christina M. Newman

    (University of Wisconsin School of Medicine and Public Health)

  • Dawn M. Dudley

    (University of Wisconsin School of Medicine and Public Health)

  • Matthew T. Aliota

    (University of Wisconsin School of Veterinary Medicine)

  • Andrea M. Weiler

    (University of Wisconsin)

  • Gabrielle L. Barry

    (University of Wisconsin)

  • Mariel S. Mohns

    (University of Wisconsin School of Medicine and Public Health)

  • Meghan E. Breitbach

    (University of Wisconsin School of Medicine and Public Health)

  • Laurel M. Stewart

    (University of Wisconsin School of Medicine and Public Health)

  • Connor R. Buechler

    (University of Wisconsin School of Medicine and Public Health)

  • Michael E. Graham

    (University of Wisconsin School of Medicine and Public Health)

  • Jennifer Post

    (University of Wisconsin)

  • Nancy Schultz-Darken

    (University of Wisconsin)

  • Eric Peterson

    (University of Wisconsin)

  • Wendy Newton

    (University of Wisconsin)

  • Emma L. Mohr

    (University of Wisconsin, University of Wisconsin Clinical Science Center)

  • Saverio Capuano

    (University of Wisconsin)

  • David H. O’Connor

    (University of Wisconsin School of Medicine and Public Health
    University of Wisconsin)

  • Thomas C. Friedrich

    (University of Wisconsin School of Veterinary Medicine
    University of Wisconsin)

Abstract

Zika virus is present in urine, saliva, tears, and breast milk, but the transmission risk associated with these body fluids is currently unknown. Here we evaluate the risk of Zika virus transmission through mucosal contact in rhesus macaques. Application of high-dose Zika virus directly to the tonsils of three rhesus macaques results in detectable plasma viremia in all animals by 2 days post-exposure; virus replication kinetics are similar to those observed in animals infected subcutaneously. Three additional macaques inoculated subcutaneously with Zika virus served as saliva donors to assess the transmission risk from contact with oral secretions from an infected individual. Seven naive animals repeatedly exposed to donor saliva via the conjunctivae, tonsils, or nostrils did not become infected. Our results suggest that there is a risk of Zika virus transmission via the mucosal route, but that the risk posed by oral secretions from individuals with a typical course of Zika virus infection is low.

Suggested Citation

  • Christina M. Newman & Dawn M. Dudley & Matthew T. Aliota & Andrea M. Weiler & Gabrielle L. Barry & Mariel S. Mohns & Meghan E. Breitbach & Laurel M. Stewart & Connor R. Buechler & Michael E. Graham & , 2017. "Oropharyngeal mucosal transmission of Zika virus in rhesus macaques," Nature Communications, Nature, vol. 8(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00246-8
    DOI: 10.1038/s41467-017-00246-8
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