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An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins

Author

Listed:
  • Song Li

    (Duke-NUS Medical School)

  • Chwee Tat Koe

    (Duke-NUS Medical School)

  • Su Ting Tay

    (Duke-NUS Medical School)

  • Angie Lay Keng Tan

    (Duke-NUS Medical School)

  • Shenli Zhang

    (Duke-NUS Medical School)

  • Yingjie Zhang

    (Duke-NUS Medical School
    National University of Singapore)

  • Patrick Tan

    (Duke-NUS Medical School
    National Cancer Centre
    National University of Singapore
    Genome Institute of Singapore)

  • Wing-Kin Sung

    (Genome Institute of Singapore
    National University of Singapore)

  • Hongyan Wang

    (Duke-NUS Medical School
    National University of Singapore
    National University of Singapore)

Abstract

The switch between quiescence and proliferation is central for neurogenesis and its alteration is linked to neurodevelopmental disorders such as microcephaly. However, intrinsic mechanisms that reactivate Drosophila larval neural stem cells (NSCs) to exit from quiescence are not well established. Here we show that the spindle matrix complex containing Chromator (Chro) functions as a key intrinsic regulator of NSC reactivation downstream of extrinsic insulin/insulin-like growth factor signalling. Chro also prevents NSCs from re-entering quiescence at later stages. NSC-specific in vivo profiling has identified many downstream targets of Chro, including a temporal transcription factor Grainy head (Grh) and a neural stem cell quiescence-inducing factor Prospero (Pros). We show that spindle matrix proteins promote the expression of Grh and repress that of Pros in NSCs to govern their reactivation. Our data demonstrate that nuclear Chro critically regulates gene expression in NSCs at the transition from quiescence to proliferation.

Suggested Citation

  • Song Li & Chwee Tat Koe & Su Ting Tay & Angie Lay Keng Tan & Shenli Zhang & Yingjie Zhang & Patrick Tan & Wing-Kin Sung & Hongyan Wang, 2017. "An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins," Nature Communications, Nature, vol. 8(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00172-9
    DOI: 10.1038/s41467-017-00172-9
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    Cited by:

    1. Yang Gao & Ye Sing Tan & Jiaen Lin & Liang Yuh Chew & Htet Yamin Aung & Brinda Palliyana & Mahekta R. Gujar & Kun-Yang Lin & Shu Kondo & Hongyan Wang, 2024. "SUMOylation of Warts kinase promotes neural stem cell reactivation," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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