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Molecular recognition by multiple metal coordination inside wavy-stacked macrocycles

Author

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  • Takashi Nakamura

    (University of Tsukuba)

  • Yuya Kaneko

    (University of Tsukuba)

  • Eiji Nishibori

    (University of Tsukuba)

  • Tatsuya Nabeshima

    (University of Tsukuba)

Abstract

Most biological and synthetic receptors for small organic molecules employ a combination of relatively weak intermolecular interactions such as hydrogen bonds. A host compound that utilizes stronger yet reversible bonding in a synergistic manner could realize precise recognition, but the regulation and spatial arrangement of such reactive interaction moieties have been a challenge. Here, we show a multinuclear zinc complex synthesized from a macrocyclic ligand hexapap, which inwardly arranges labile metal coordination sites for external molecules. The metallomacrocycle forms a unique wavy-stacked structure upon binding a suitable length of dicarboxylic acids via multipoint coordination bonding. The saddle-shaped deformation and dimerization realize the differentiation of the interaction moieties, and change of guest-binding modes at specific metal coordination sites among the many present have been achieved utilizing acid/base as external stimuli.

Suggested Citation

  • Takashi Nakamura & Yuya Kaneko & Eiji Nishibori & Tatsuya Nabeshima, 2017. "Molecular recognition by multiple metal coordination inside wavy-stacked macrocycles," Nature Communications, Nature, vol. 8(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00076-8
    DOI: 10.1038/s41467-017-00076-8
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