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Precise inhibitory microcircuit assembly of developmentally related neocortical interneurons in clusters

Author

Listed:
  • Xin-Jun Zhang

    (Developmental Biology Program, Memorial Sloan Kettering Cancer Center)

  • Zhizhong Li

    (Developmental Biology Program, Memorial Sloan Kettering Cancer Center)

  • Zhi Han

    (The Ohio State University
    College of Software, Nankai University)

  • Khadeejah T. Sultan

    (Developmental Biology Program, Memorial Sloan Kettering Cancer Center
    Graduate Program in Neuroscience, Weill Cornell Medical College)

  • Kun Huang

    (The Ohio State University)

  • Song-Hai Shi

    (Developmental Biology Program, Memorial Sloan Kettering Cancer Center
    Graduate Program in Neuroscience, Weill Cornell Medical College)

Abstract

GABA-ergic interneurons provide diverse inhibitions that are essential for the operation of neuronal circuits in the neocortex. However, the mechanisms that control the functional organization of neocortical interneurons remain largely unknown. Here we show that developmental origins influence fine-scale synapse formation and microcircuit assembly of neocortical interneurons. Spatially clustered neocortical interneurons originating from low-titre retrovirus-infected radial glial progenitors in the embryonic medial ganglionic eminence and preoptic area preferentially develop electrical, but not chemical, synapses with each other. This lineage-related electrical coupling forms predominantly between the same interneuron subtype over an extended postnatal period and across a range of distances, and promotes action potential generation and synchronous firing. Interestingly, this selective electrical coupling relates to a coordinated inhibitory chemical synapse formation between sparsely labelled interneurons in clusters and the same nearby excitatory neurons. These results suggest a link between the lineage relationship of neocortical interneurons and their precise functional organization.

Suggested Citation

  • Xin-Jun Zhang & Zhizhong Li & Zhi Han & Khadeejah T. Sultan & Kun Huang & Song-Hai Shi, 2017. "Precise inhibitory microcircuit assembly of developmentally related neocortical interneurons in clusters," Nature Communications, Nature, vol. 8(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms16091
    DOI: 10.1038/ncomms16091
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    Cited by:

    1. Yoav Printz & Pritish Patil & Mathias Mahn & Asaf Benjamin & Anna Litvin & Rivka Levy & Max Bringmann & Ofer Yizhar, 2023. "Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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