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Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells

Author

Listed:
  • Michel Enamorado

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC))

  • Salvador Iborra

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC))

  • Elena Priego

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
    Universidad Autónoma de Madrid)

  • Francisco J. Cueto

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
    Universidad Autónoma de Madrid)

  • Juan A. Quintana

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC))

  • Sarai Martínez-Cano

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC))

  • Ernesto Mejías-Pérez

    (Centro Nacional de Biotecnología)

  • Mariano Esteban

    (Centro Nacional de Biotecnología)

  • Ignacio Melero

    (Center for Applied Medical Research (CIMA), Centro de Investigación Biomédica en Red de Cáncer (CIBERONC)
    University Clinic, University of Navarra and Instituto de Investigación Sanitaria de Navarra (IdISNA))

  • Andrés Hidalgo

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
    Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität)

  • David Sancho

    (Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC))

Abstract

The goal of successful anti-tumoural immunity is the development of long-term protective immunity to prevent relapse. Infiltration of tumours with CD8+ T cells with a resident memory (Trm) phenotype correlates with improved survival. However, the interplay of circulating CD8+ T cells and Trm cells remains poorly explored in tumour immunity. Using different vaccination strategies that fine-tune the generation of Trm cells or circulating memory T cells, here we show that, while both subsets are sufficient for anti-tumour immunity, the presence of Trm cells improves anti-tumour efficacy. Transferred central memory T cells (Tcm) generate Trm cells following viral infection or tumour challenge. Anti-PD-1 treatment promotes infiltration of transferred Tcm cells within tumours, improving anti-tumour immunity. Moreover, Batf3-dependent dendritic cells are essential for reactivation of circulating memory anti-tumour response. Our findings show the plasticity, collaboration and requirements for reactivation of memory CD8+ T cells subsets needed for optimal tumour vaccination and immunotherapy.

Suggested Citation

  • Michel Enamorado & Salvador Iborra & Elena Priego & Francisco J. Cueto & Juan A. Quintana & Sarai Martínez-Cano & Ernesto Mejías-Pérez & Mariano Esteban & Ignacio Melero & Andrés Hidalgo & David Sanch, 2017. "Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells," Nature Communications, Nature, vol. 8(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms16073
    DOI: 10.1038/ncomms16073
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    Cited by:

    1. Curtis J. Pritzl & Dezzarae Luera & Karin M. Knudson & Michael J. Quaney & Michael J. Calcutt & Mark A. Daniels & Emma Teixeiro, 2023. "IKK2/NFkB signaling controls lung resident CD8+ T cell memory during influenza infection," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Sumin Jo & Shipra Das & Alan Williams & Anne-Sophie Chretien & Thomas Pagliardini & Aude Roy & Jorge Postigo Fernandez & Diane Clerre & Billal Jahangiri & Isabelle Chion-Sotinel & Sandra Rozlan & Emil, 2022. "Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editing," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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