IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_ncomms16032.html
   My bibliography  Save this article

Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum

Author

Listed:
  • Jean Simonnet

    (Inserm U1127, CNRS UMR7225, Sorbonne Universités, UPMC Univ Paris 6 UMR S1127, Institut du Cerveau et de la Moelle Épinière
    Present address: Bernstein Center for Computational Neuroscience, Humboldt University of Berlin, Philippstrasse 13, Haus 6, 10115 Berlin, Germany)

  • Mérie Nassar

    (Inserm U1127, CNRS UMR7225, Sorbonne Universités, UPMC Univ Paris 6 UMR S1127, Institut du Cerveau et de la Moelle Épinière
    CNRS UMR 8119, Université Paris Descartes)

  • Federico Stella

    (Institut of Science and Technology Austria)

  • Ivan Cohen

    (INSERM U1130, CNRS UMR8246, Sorbonne Universités, UPMC Univ Paris 6 UM CR 18, Neuroscience Paris Seine)

  • Bertrand Mathon

    (Inserm U1127, CNRS UMR7225, Sorbonne Universités, UPMC Univ Paris 6 UMR S1127, Institut du Cerveau et de la Moelle Épinière)

  • Charlotte N. Boccara

    (Institut of Science and Technology Austria)

  • Richard Miles

    (Inserm U1127, CNRS UMR7225, Sorbonne Universités, UPMC Univ Paris 6 UMR S1127, Institut du Cerveau et de la Moelle Épinière)

  • Desdemona Fricker

    (Inserm U1127, CNRS UMR7225, Sorbonne Universités, UPMC Univ Paris 6 UMR S1127, Institut du Cerveau et de la Moelle Épinière
    CNRS UMR 8119, Université Paris Descartes
    Present address: Université Paris Descartes, CNRS UMR 8119, 45 rue des St-Pères, 75006 Paris, France)

Abstract

Orientation in space is represented in specialized brain circuits. Persistent head direction signals are transmitted from anterior thalamus to the presubiculum, but the identity of the presubicular target neurons, their connectivity and function in local microcircuits are unknown. Here, we examine how thalamic afferents recruit presubicular principal neurons and Martinotti interneurons, and the ensuing synaptic interactions between these cells. Pyramidal neuron activation of Martinotti cells in superficial layers is strongly facilitating such that high-frequency head directional stimulation efficiently unmutes synaptic excitation. Martinotti-cell feedback plays a dual role: precisely timed spikes may not inhibit the firing of in-tune head direction cells, while exerting lateral inhibition. Autonomous attractor dynamics emerge from a modelled network implementing wiring motifs and timing sensitive synaptic interactions in the pyramidal—Martinotti-cell feedback loop. This inhibitory microcircuit is therefore tuned to refine and maintain head direction information in the presubiculum.

Suggested Citation

  • Jean Simonnet & Mérie Nassar & Federico Stella & Ivan Cohen & Bertrand Mathon & Charlotte N. Boccara & Richard Miles & Desdemona Fricker, 2017. "Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum," Nature Communications, Nature, vol. 8(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms16032
    DOI: 10.1038/ncomms16032
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms16032
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms16032?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Kevin K. Sit & Michael J. Goard, 2023. "Coregistration of heading to visual cues in retrosplenial cortex," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms16032. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.