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Differential processing of thalamic information via distinct striatal interneuron circuits

Author

Listed:
  • Maxime Assous

    (Center for Molecular and Behavioral Neuroscience, Rutgers University)

  • Jaime Kaminer

    (Center for Molecular and Behavioral Neuroscience, Rutgers University)

  • Fulva Shah

    (Center for Molecular and Behavioral Neuroscience, Rutgers University)

  • Arpan Garg

    (Center for Molecular and Behavioral Neuroscience, Rutgers University)

  • Tibor Koós

    (Center for Molecular and Behavioral Neuroscience, Rutgers University)

  • James M. Tepper

    (Center for Molecular and Behavioral Neuroscience, Rutgers University)

Abstract

Recent discoveries of striatal GABAergic interneurons require a new conceptualization of the organization of intrastriatal circuitry and their cortical and thalamic inputs. We investigated thalamic inputs to the two populations of striatal neuropeptide Y (NPY) interneurons, plateau low threshold spike (PLTS) and NPY-neurogliaform (NGF) cells. Optogenetic activation of parafascicular inputs evokes suprathreshold monosynaptic glutamatergic excitation in NGF interneurons and a disynaptic, nicotinic excitation through cholinergic interneurons. In contrast, the predominant response of PLTS interneurons is a disynaptic inhibition dependent on thalamic activation of striatal tyrosine hydroxylase interneurons (THINs). In contrast, THINs do not innervate NGF or fast spiking interneurons, showing significant specificity in THINs outputs. Chemospecific ablation of THINs impairs prepulse inhibition of the acoustic startle response suggesting an important behavioural role of this disynaptic pathway. Our findings demonstrate that the impact of the parafascicular nucleus on striatal activity and some related behaviour critically depend on synaptic interactions within interneuronal circuits.

Suggested Citation

  • Maxime Assous & Jaime Kaminer & Fulva Shah & Arpan Garg & Tibor Koós & James M. Tepper, 2017. "Differential processing of thalamic information via distinct striatal interneuron circuits," Nature Communications, Nature, vol. 8(1), pages 1-14, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15860
    DOI: 10.1038/ncomms15860
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    1. Yang Chen & Yuhao Gu & Bianbian Wang & Anqi Wei & Nan Dong & Yong Jiang & Xiaoying Liu & Li Zhu & Feng Zhu & Tao Tan & Zexin Jing & Fenghan Mao & Yichi Zhang & Jingyu Yao & Yuxin Yang & Hongyan Wang &, 2024. "Synaptotagmin-11 deficiency mediates schizophrenia-like behaviors in mice via dopamine over-transmission," Nature Communications, Nature, vol. 15(1), pages 1-23, December.

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