IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_ncomms15805.html
   My bibliography  Save this article

Genetic loci associated with heart rate variability and their effects on cardiac disease risk

Author

Listed:
  • Ilja M. Nolte

    (University of Groningen, University Medical Center Groningen)

  • M. Loretto Munoz

    (University of Groningen, University Medical Center Groningen)

  • Vinicius Tragante

    (University Medical Center Utrecht)

  • Azmeraw T. Amare

    (University of Groningen, University Medical Center Groningen
    School of Medicine, University of Adelaide
    College of Medicine and Health Sciences, Bahir Dar University)

  • Rick Jansen

    (EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest)

  • Ahmad Vaez

    (University of Groningen, University Medical Center Groningen
    School of Medicine, Isfahan University of Medical Sciences)

  • Benedikt von der Heyde

    (Molecular Epidemiology, Uppsala University
    Science for Life Laboratory, Uppsala University)

  • Christy L. Avery

    (Gillings School of Global Public Health, University of North Carolina)

  • Joshua C. Bis

    (Cardiovascular Health Research Unit, University of Washington)

  • Bram Dierckx

    (Department of Child and Adolescent Psychiatry/Psychology, Department of Child and Adolescent Psychiatry
    The Generation R Study Group, Erasmus MC)

  • Jenny van Dongen

    (Behavioral and Movement Sciences, VU University)

  • Stephanie M. Gogarten

    (School of Public Health, University of Washington)

  • Philippe Goyette

    (Montreal Heart Institute)

  • Jussi Hernesniemi

    (Fimlab Laboratories
    University of Tampere School of Medicine
    Heart Hospital, Tampere University Hospital)

  • Ville Huikari

    (Center for Life Course Health Research, University of Oulu)

  • Shih-Jen Hwang

    (Framingham Heart Study
    Population Sciences Branch, National Heart, Lung and Blood Institute)

  • Deepali Jaju

    (Sultan Qaboos University Hospital)

  • Kathleen F. Kerr

    (School of Public Health, University of Washington)

  • Alexander Kluttig

    (Institute of Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg)

  • Bouwe P. Krijthe

    (Erasmus MC, University Medical Center Rotterdam)

  • Jitender Kumar

    (Molecular Epidemiology, Uppsala University
    Science for Life Laboratory, Uppsala University)

  • Sander W. van der Laan

    (Laboratory of Experimental Cardiology, University Medical Center Utrecht)

  • Leo-Pekka Lyytikäinen

    (Fimlab Laboratories
    University of Tampere School of Medicine)

  • Adam X. Maihofer

    (University of California, San Diego
    Center for Stress and Mental Health (CESAMH), VA San Diego Healthcare System)

  • Arpi Minassian

    (University of California, San Diego
    Center for Stress and Mental Health (CESAMH), VA San Diego Healthcare System)

  • Peter J. van der Most

    (University of Groningen, University Medical Center Groningen)

  • Martina Müller-Nurasyid

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health
    University Hospital Munich, Ludwig-Maximilians-University
    DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance)

  • Michel Nivard

    (Behavioral and Movement Sciences, VU University
    EMGO+ Institute for Health and Care Research, VU University & VU University Medical Center)

  • Erika Salvi

    (University of Milano)

  • James D. Stewart

    (Gillings School of Global Public Health, University of North Carolina
    Carolina Population Center, University of North Carolina)

  • Julian F. Thayer

    (The Ohio State University)

  • Niek Verweij

    (University of Groningen, University Medical Center Groningen)

  • Andrew Wong

    (MRC Unit for Lifelong Health and Ageing, University College London)

  • Delilah Zabaneh

    (Institute of Psychiatry, Psychology & Neuroscience, King's College London
    University College London Genetics Institute, University College London)

  • Mohammad H. Zafarmand

    (Academic Medical Center (AMC), University of Amsterdam
    Academic Medical Centre, University of Amsterdam)

  • Abdel Abdellaoui

    (Behavioral and Movement Sciences, VU University
    EMGO+ Institute for Health and Care Research, VU University & VU University Medical Center)

  • Sulayma Albarwani

    (College of Medicine and Health Sciences, Sultan Qaboos University)

  • Christine Albert

    (Brigham and Women's Hospital, Harvard Medical School)

  • Alvaro Alonso

    (Rollins School of Public Health, Emory University)

  • Foram Ashar

    (McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine)

  • Juha Auvinen

    (Center for Life Course Health Research, University of Oulu
    Unit of Primary Health Care, Oulu University Hospital)

  • Tomas Axelsson

    (Molecular Medicine, Uppsala University)

  • Dewleen G. Baker

    (University of California, San Diego
    Center for Stress and Mental Health (CESAMH), VA San Diego Healthcare System)

  • Paul I. W. de Bakker

    (Center for Molecular Medicine, University Medical Center Utrecht
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht)

  • Matteo Barcella

    (University of Milano)

  • Riad Bayoumi

    (College of Medicine, Mohammed Bin Rashid University)

  • Rob J. Bieringa

    (University of Groningen, University Medical Center Groningen)

  • Dorret Boomsma

    (Behavioral and Movement Sciences, VU University
    EMGO+ Institute for Health and Care Research, VU University & VU University Medical Center)

  • Gabrielle Boucher

    (Montreal Heart Institute)

  • Annie R. Britton

    (University College London)

  • Ingrid Christophersen

    (Cardiovascular Research Center, Massachusetts General Hospital
    Program in Medical and Population Genetics, The Broad Institute of Harvard and MIT
    Bærum Hospital, Vestre Viken Hospital Trust)

  • Andrea Dietrich

    (University of Groningen, University Medical Center Groningen)

  • George B. Ehret

    (Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine
    Cardiology, Geneva University Hospital)

  • Patrick T. Ellinor

    (Program in Medical and Population Genetics, The Broad Institute of Harvard and MIT
    Cardiac Arrhythmia Service & Cardiovascular Research Center, Massachusetts General Hospital)

  • Markku Eskola

    (Heart Hospital, Tampere University Hospital
    University of Tampere School of Medicine)

  • Janine F. Felix

    (Erasmus MC, University Medical Center Rotterdam)

  • John S. Floras

    (University of Toronto
    Toronto General Research Institute, University Health Network)

  • Oscar H. Franco

    (Erasmus MC, University Medical Center Rotterdam)

  • Peter Friberg

    (Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg)

  • Maaike G. J. Gademan

    (Academic Medical Center (AMC), University of Amsterdam)

  • Mark A. Geyer

    (University of California, San Diego)

  • Vilmantas Giedraitis

    (Molecular Geriatrics, Uppsala University)

  • Catharina A. Hartman

    (Interdisciplinary Center Psychopathology and Emotion regulation, University of Groningen, University Medical Center Groningen)

  • Daiane Hemerich

    (University Medical Center Utrecht
    CAPES Foundation, Ministry of Education of Brazil)

  • Albert Hofman

    (Erasmus MC, University Medical Center Rotterdam)

  • Jouke-Jan Hottenga

    (Behavioral and Movement Sciences, VU University
    EMGO+ Institute for Health and Care Research, VU University & VU University Medical Center)

  • Heikki Huikuri

    (Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu)

  • Nina Hutri-Kähönen

    (Tampere University Hospital
    University of Tampere School of Medicine)

  • Xavier Jouven

    (INSERM U970, Paris Descartes University)

  • Juhani Junttila

    (Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu)

  • Markus Juonala

    (University of Turku
    Turku University Hospital)

  • Antti M. Kiviniemi

    (Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu)

  • Jan A. Kors

    (Erasmus Medical Center)

  • Meena Kumari

    (University College London
    ISER, Essex University)

  • Tatiana Kuznetsova

    (Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, University of Leuven)

  • Cathy C. Laurie

    (School of Public Health, University of Washington)

  • Joop D. Lefrandt

    (University of Groningen, University Medical Center Groningen)

  • Yong Li

    (Institute for Medical Biometry and Statistics, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg)

  • Yun Li

    (University of North Carolina
    University of North Carolina
    University of North Carolina)

  • Duanping Liao

    (Penn State University College of Medicine)

  • Marian C. Limacher

    (University of Florida College of Medicine)

  • Henry J. Lin

    (Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
    Harbor-UCLA Medical Center)

  • Cecilia M. Lindgren

    (Li Ka Shing Centre for Health Information and Discovery, The Big Data Institute, University of Oxford
    Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Steven A. Lubitz

    (Program in Medical and Population Genetics, The Broad Institute of Harvard and MIT
    Cardiac Arrhythmia Service & Cardiovascular Research Center, Massachusetts General Hospital)

  • Anubha Mahajan

    (Wellcome Trust Centre for Human Genetics, University of Oxford)

  • Barbara McKnight

    (Cardiovascular Health Research Unit, University of Washington
    School of Public Health, University of Washington
    Fred Hutchinson Cancer Research Center)

  • Henriette Meyer zu Schwabedissen

    (Biopharmacy, University of Basel)

  • Yuri Milaneschi

    (EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest)

  • Nina Mononen

    (Fimlab Laboratories
    University of Tampere School of Medicine)

  • Andrew P. Morris

    (Wellcome Trust Centre for Human Genetics, University of Oxford
    University of Liverpool)

  • Mike A. Nalls

    (Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health)

  • Gerjan Navis

    (University of Groningen, University Medical Center Groningen)

  • Melanie Neijts

    (Behavioral and Movement Sciences, VU University
    EMGO+ Institute for Health and Care Research, VU University & VU University Medical Center)

  • Kjell Nikus

    (Heart Hospital, Tampere University Hospital
    University of Tampere, School of Medicine)

  • Kari E. North

    (Gillings School of Global Public Health, University of North Carolina
    Carolina Center for Genome Sciences, University of North Carolina)

  • Daniel T. O'Connor

    (University of California, San Diego)

  • Johan Ormel

    (Interdisciplinary Center Psychopathology and Emotion regulation, University of Groningen, University Medical Center Groningen)

  • Siegfried Perz

    (Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health)

  • Annette Peters

    (DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance
    Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health
    German Center for Diabetes Research)

  • Bruce M. Psaty

    (Cardiovascular Health Research Unit, University of Washington
    University of Washington
    Group Health Research Institute, Group Health Cooperative)

  • Olli T. Raitakari

    (Turku University Hospital
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku)

  • Victoria B. Risbrough

    (University of California, San Diego
    Center for Stress and Mental Health (CESAMH), VA San Diego Healthcare System)

  • Moritz F. Sinner

    (University Hospital Munich, Ludwig-Maximilians-University
    DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance)

  • David Siscovick

    (The New York Academy of Medicine)

  • Johannes H. Smit

    (EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest)

  • Nicholas L. Smith

    (Group Health Research Institute, Group Health Cooperative
    School of Public Health, University of Washington
    Seattle Epidemiologic Research and Information Center, Veterans Affairs Office of Research and Development)

  • Elsayed Z. Soliman

    (Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine)

  • Nona Sotoodehnia

    (Cardiovascular Health Research Unit, University of Washington)

  • Jan A. Staessen

    (Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, University of Leuven)

  • Phyllis K. Stein

    (Heart Rate Variability Lab, Washington University School of Medicine)

  • Adrienne M. Stilp

    (School of Public Health, University of Washington)

  • Katarzyna Stolarz-Skrzypek

    (Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College)

  • Konstantin Strauch

    (Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health
    Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität)

  • Johan Sundström

    (Cardiovascular Epidemiology, Uppsala University)

  • Cees A. Swenne

    (Leiden University Medical Center)

  • Ann-Christine Syvänen

    (Molecular Medicine, Uppsala University)

  • Jean-Claude Tardif

    (Montreal Heart Institute
    Université de Montréal)

  • Kent D. Taylor

    (Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center)

  • Alexander Teumer

    (Institute for Community Medicine, University Medicine Greifswald)

  • Timothy A. Thornton

    (School of Public Health, University of Washington)

  • Lesley E. Tinker

    (Fred Hutchinson Cancer Research Center)

  • André G. Uitterlinden

    (Erasmus MC, University Medical Center Rotterdam
    Erasmus University Medical Center
    Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging NCHA))

  • Jessica van Setten

    (University Medical Center Utrecht)

  • Andreas Voss

    (Institute of Innovative Health Technologies—IGHT Jena Ernst-Abbe-Hochschule Jena)

  • Melanie Waldenberger

    (Institute of Epidemiology II, Helmholtz Zentrum München—German Research Center for Environmental Health
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health)

  • Kirk C. Wilhelmsen

    (Departments of Genetics and Neurology University of North Carolina
    The Renaissance Computing Institute)

  • Gonneke Willemsen

    (Behavioral and Movement Sciences, VU University
    EMGO+ Institute for Health and Care Research, VU University & VU University Medical Center)

  • Quenna Wong

    (School of Public Health, University of Washington)

  • Zhu-Ming Zhang

    (Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine
    Wake Forest School of Medicine)

  • Alan B. Zonderman

    (Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health)

  • Daniele Cusi

    (Institute of Biomedical Technologies, CNR—Italian National Research Council
    KOS Genetic SRL)

  • Michele K. Evans

    (Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health)

  • Halina K. Greiser

    (German Cancer Research Centre)

  • Pim van der Harst

    (University of Groningen, University Medical Center Groningen)

  • Mohammad Hassan

    (College of Medicine and Health Sciences, Sultan Qaboos University)

  • Erik Ingelsson

    (Molecular Epidemiology, Uppsala University
    Science for Life Laboratory, Uppsala University
    Stanford University School of Medicine)

  • Marjo-Riitta Järvelin

    (Center for Life Course Health Research, University of Oulu
    Unit of Primary Health Care, Oulu University Hospital
    School of Public Health, Faculty of Medicine, St Mary’s campus, Imperial College London
    Biocenter Oulu University of Oulu)

  • Stefan Kääb

    (University Hospital Munich, Ludwig-Maximilians-University
    DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance)

  • Mika Kähönen

    (Tampere University Hospital
    University of Tampere, School of Medicine)

  • Mika Kivimaki

    (University College London)

  • Charles Kooperberg

    (Fred Hutchinson Cancer Research Center)

  • Diana Kuh

    (MRC Unit for Lifelong Health and Ageing, University College London)

  • Terho Lehtimäki

    (Fimlab Laboratories
    University of Tampere School of Medicine)

  • Lars Lind

    (Cardiovascular Epidemiology, Uppsala University)

  • Caroline M. Nievergelt

    (University of California, San Diego
    Center for Stress and Mental Health (CESAMH), VA San Diego Healthcare System)

  • Chris J. O'Donnell

    (Framingham Heart Study
    Population Sciences Branch, National Heart, Lung and Blood Institute
    Cardiology Section, Boston Veteran’s Administration Healthcare)

  • Albertine J. Oldehinkel

    (Interdisciplinary Center Psychopathology and Emotion regulation, University of Groningen, University Medical Center Groningen)

  • Brenda Penninx

    (EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center/GGZ inGeest)

  • Alexander P. Reiner

    (Fred Hutchinson Cancer Research Center
    School of Public Health, University of Washington)

  • Harriëtte Riese

    (Interdisciplinary Center Psychopathology and Emotion regulation, University of Groningen, University Medical Center Groningen)

  • Arie M. van Roon

    (University of Groningen, University Medical Center Groningen)

  • John D. Rioux

    (Montreal Heart Institute
    Université de Montréal)

  • Jerome I. Rotter

    (Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center)

  • Tamar Sofer

    (School of Public Health, University of Washington)

  • Bruno H. Stricker

    (Erasmus MC, University Medical Center Rotterdam
    Inspectorate for Health Care)

  • Henning Tiemeier

    (Department of Child and Adolescent Psychiatry/Psychology, Department of Child and Adolescent Psychiatry
    Erasmus MC, University Medical Center Rotterdam)

  • Tanja G. M. Vrijkotte

    (Academic Medical Center (AMC), University of Amsterdam)

  • Folkert W. Asselbergs

    (University Medical Center Utrecht
    Institute of Cardiovascular Science, University College London
    Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute)

  • Bianca J. J. M. Brundel

    (Institute for Cardiovascular Research, VU University Medical Center)

  • Susan R. Heckbert

    (Cardiovascular Health Research Unit, University of Washington
    School of Public Health, University of Washington)

  • Eric A. Whitsel

    (Gillings School of Global Public Health, University of North Carolina
    University of North Carolina)

  • Marcel den Hoed

    (Molecular Epidemiology, Uppsala University
    Science for Life Laboratory, Uppsala University)

  • Harold Snieder

    (University of Groningen, University Medical Center Groningen)

  • Eco J. C. de Geus

    (Behavioral and Movement Sciences, VU University
    EMGO+ Institute for Health and Care Research, VU University & VU University Medical Center)

Abstract

Reduced cardiac vagal control reflected in low heart rate variability (HRV) is associated with greater risks for cardiac morbidity and mortality. In two-stage meta-analyses of genome-wide association studies for three HRV traits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in eight loci. HRV SNPs tag non-synonymous SNPs (in NDUFA11 and KIAA1755), expression quantitative trait loci (eQTLs) (influencing GNG11, RGS6 and NEO1), or are located in genes preferentially expressed in the sinoatrial node (GNG11, RGS6 and HCN4). Genetic risk scores account for 0.9 to 2.6% of the HRV variance. Significant genetic correlation is found for HRV with heart rate (−0.74

Suggested Citation

  • Ilja M. Nolte & M. Loretto Munoz & Vinicius Tragante & Azmeraw T. Amare & Rick Jansen & Ahmad Vaez & Benedikt von der Heyde & Christy L. Avery & Joshua C. Bis & Bram Dierckx & Jenny van Dongen & Steph, 2017. "Genetic loci associated with heart rate variability and their effects on cardiac disease risk," Nature Communications, Nature, vol. 8(1), pages 1-17, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15805
    DOI: 10.1038/ncomms15805
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms15805
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms15805?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15805. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.