IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_ncomms15782.html
   My bibliography  Save this article

Dynamic contrast-enhanced photoacoustic imaging using photothermal stimuli-responsive composite nanomodulators

Author

Listed:
  • Yun-Sheng Chen

    (Stanford University)

  • Soon Joon Yoon

    (The University of Texas at Austin
    The University of Texas at Austin)

  • Wolfgang Frey

    (The University of Texas at Austin)

  • Mary Dockery

    (The University of Texas at Austin)

  • Stanislav Emelianov

    (School of Electrical and Computer Engineering, Georgia Institute of Technology
    Georgia Institute of Technology and Emory University School of Medicine)

Abstract

Molecular photoacoustic imaging has shown great potential in medical applications; its sensitivity is normally in pico-to-micro-molar range, dependent on exogenous imaging agents. However, tissue can produce strong background signals, which mask the signals from the imaging agents, resulting in orders of magnitude sensitivity reduction. As such, an elaborate spectral scan is often required to spectrally un-mix the unwanted background signals. Here we show a new single-wavelength photoacoustic dynamic contrast-enhanced imaging technique by employing a stimuli-responsive contrast agent. Our technique can eliminate intrinsic background noises without significant hardware or computational resources. We show that this new contrast agent can generate up to 30 times stronger photoacoustic signals than the concentration-matched inorganic nanoparticle counterparts. By dynamically modulating signals from the contrast agents with an external near-infrared optical stimulus, we can further suppress the background signals leading to an additional increase of more than five-fold in imaging contrast in vivo.

Suggested Citation

  • Yun-Sheng Chen & Soon Joon Yoon & Wolfgang Frey & Mary Dockery & Stanislav Emelianov, 2017. "Dynamic contrast-enhanced photoacoustic imaging using photothermal stimuli-responsive composite nanomodulators," Nature Communications, Nature, vol. 8(1), pages 1-10, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15782
    DOI: 10.1038/ncomms15782
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms15782
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms15782?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Shensheng Zhao & Jonathan Hartanto & Ritin Joseph & Cheng-Hsun Wu & Yang Zhao & Yun-Sheng Chen, 2023. "Hybrid photoacoustic and fast super-resolution ultrasound imaging," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15782. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.