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DNA vaccination protects mice against Zika virus-induced damage to the testes

Author

Listed:
  • Bryan D. Griffin

    (Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada
    University of Manitoba)

  • Kar Muthumani

    (The Wistar Institute)

  • Bryce M. Warner

    (University of Manitoba
    Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada)

  • Anna Majer

    (Molecular Pathobiology, National Microbiology Laboratory, Public Health Agency of Canada)

  • Mable Hagan

    (Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada
    University of Manitoba)

  • Jonathan Audet

    (Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada
    University of Manitoba)

  • Derek R. Stein

    (University of Manitoba
    Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada)

  • Charlene Ranadheera

    (University of Manitoba
    Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada)

  • Trina Racine

    (Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada
    Faculty of Medicine, Laval University)

  • Marc-Antoine De La Vega

    (Faculty of Medicine, Laval University)

  • Jocelyne Piret

    (Research Center in Infectious Diseases of the CHU of Québec and Laval University)

  • Stephanie Kucas

    (Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada
    Veterinary Technical Services, Public Health Agency of Canada, National Microbiology Laboratory)

  • Kaylie N. Tran

    (Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada)

  • Kathy L. Frost

    (Molecular Pathobiology, National Microbiology Laboratory, Public Health Agency of Canada)

  • Christine De Graff

    (Veterinary Technical Services, Public Health Agency of Canada, National Microbiology Laboratory)

  • Geoff Soule

    (Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada)

  • Leanne Scharikow

    (Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada)

  • Jennifer Scott

    (Heartland Fertility & Gynecology Clinic)

  • Gordon McTavish

    (Heartland Fertility & Gynecology Clinic)

  • Valerie Smid

    (National Centre for Foreign Animal Disease, Canadian Food Inspection Agency)

  • Young K. Park

    (GeneOne Life Science Inc.)

  • Joel N. Maslow

    (GeneOne Life Science Inc.)

  • Niranjan Y. Sardesai

    (Inovio Pharmaceuticals Inc.)

  • J. Joseph Kim

    (Inovio Pharmaceuticals Inc.)

  • Xiao-jian Yao

    (University of Manitoba)

  • Alexander Bello

    (Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada
    University of Manitoba)

  • Robbin Lindsay

    (University of Manitoba
    Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada)

  • Guy Boivin

    (Research Center in Infectious Diseases of the CHU of Québec and Laval University)

  • Stephanie A. Booth

    (University of Manitoba
    Molecular Pathobiology, National Microbiology Laboratory, Public Health Agency of Canada)

  • Darwyn Kobasa

    (Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada
    University of Manitoba)

  • Carissa Embury-Hyatt

    (National Centre for Foreign Animal Disease, Canadian Food Inspection Agency)

  • David Safronetz

    (University of Manitoba
    Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada)

  • David B. Weiner

    (The Wistar Institute)

  • Gary P. Kobinger

    (Faculty of Medicine, Laval University
    University of Pennsylvania School of Medicine)

Abstract

Zika virus (ZIKV) is an emerging pathogen causally associated with serious sequelae in fetuses, inducing fetal microcephaly and other neurodevelopment defects. ZIKV is primarily transmitted by mosquitoes, but can persist in human semen and sperm, and sexual transmission has been documented. Moreover, exposure of type-I interferon knockout mice to ZIKV results in severe damage to the testes, epididymis and sperm. Candidate ZIKV vaccines have shown protective efficacy in preclinical studies carried out in animal models, and several vaccines have entered clinical trials. Here, we report that administration of a synthetic DNA vaccine encoding ZIKV pre-membrane and envelope (prME) completely protects mice against ZIKV-associated damage to the testes and sperm and prevents viral persistence in the testes following challenge with a contemporary strain of ZIKV. These data suggest that DNA vaccination merits further investigation as a potential means to reduce ZIKV persistence in the male reproductive tract.

Suggested Citation

  • Bryan D. Griffin & Kar Muthumani & Bryce M. Warner & Anna Majer & Mable Hagan & Jonathan Audet & Derek R. Stein & Charlene Ranadheera & Trina Racine & Marc-Antoine De La Vega & Jocelyne Piret & Stepha, 2017. "DNA vaccination protects mice against Zika virus-induced damage to the testes," Nature Communications, Nature, vol. 8(1), pages 1-8, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15743
    DOI: 10.1038/ncomms15743
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