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Genome-wide association study identifies multiple risk loci for renal cell carcinoma

Author

Listed:
  • Ghislaine Scelo

    (International Agency for Research on Cancer (IARC))

  • Mark P. Purdue

    (National Cancer Institute, National Institutes of Health)

  • Kevin M. Brown

    (National Cancer Institute, National Institutes of Health)

  • Mattias Johansson

    (International Agency for Research on Cancer (IARC))

  • Zhaoming Wang

    (St Jude Children's Research Hospital)

  • Jeanette E. Eckel-Passow

    (Mayo Clinic)

  • Yuanqing Ye

    (The University of Texas MD Anderson Cancer Center)

  • Jonathan N. Hofmann

    (National Cancer Institute, National Institutes of Health)

  • Jiyeon Choi

    (National Cancer Institute, National Institutes of Health)

  • Matthieu Foll

    (International Agency for Research on Cancer (IARC))

  • Valerie Gaborieau

    (International Agency for Research on Cancer (IARC))

  • Mitchell J. Machiela

    (National Cancer Institute, National Institutes of Health)

  • Leandro M. Colli

    (National Cancer Institute, National Institutes of Health)

  • Peng Li

    (International Agency for Research on Cancer (IARC))

  • Joshua N. Sampson

    (National Cancer Institute, National Institutes of Health)

  • Behnoush Abedi-Ardekani

    (International Agency for Research on Cancer (IARC))

  • Celine Besse

    (Centre National de Genotypage, Institut de Genomique, Commissariat à l'Energie Atomique et aux Energies Alternatives)

  • Helene Blanche

    (Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain)

  • Anne Boland

    (Centre National de Genotypage, Institut de Genomique, Commissariat à l'Energie Atomique et aux Energies Alternatives)

  • Laurie Burdette

    (National Cancer Institute, National Institutes of Health)

  • Amelie Chabrier

    (International Agency for Research on Cancer (IARC))

  • Geoffroy Durand

    (International Agency for Research on Cancer (IARC))

  • Florence Le Calvez-Kelm

    (International Agency for Research on Cancer (IARC))

  • Egor Prokhortchouk

    (Center ‘Bioengineering’ of the Russian Academy of Sciences
    Kurchatov Scientific Center)

  • Nivonirina Robinot

    (International Agency for Research on Cancer (IARC))

  • Konstantin G. Skryabin

    (Center ‘Bioengineering’ of the Russian Academy of Sciences
    Kurchatov Scientific Center)

  • Magdalena B. Wozniak

    (International Agency for Research on Cancer (IARC))

  • Meredith Yeager

    (National Cancer Institute, National Institutes of Health)

  • Gordana Basta-Jovanovic

    (Institute of Pathology, School of Medicine, University of Belgrade)

  • Zoran Dzamic

    (Clinical Center of Serbia (KCS), Clinic of Urology, University of Belgrade-Faculty of Medicine)

  • Lenka Foretova

    (Masaryk Memorial Cancer Institute)

  • Ivana Holcatova

    (2nd Faculty of Medicine, Institute of Public Health and Preventive Medicine, Charles University)

  • Vladimir Janout

    (Faculty of Medicine, Palacky University)

  • Dana Mates

    (National Institute of Public Health)

  • Anush Mukeriya

    (Russian N.N. Blokhin Cancer Research Centre)

  • Stefan Rascu

    (Carol Davila University of Medicine and Pharmacy, Th. Burghele Hospital)

  • David Zaridze

    (Russian N.N. Blokhin Cancer Research Centre)

  • Vladimir Bencko

    (First Faculty of Medicine, Institute of Hygiene and Epidemiology, Charles University)

  • Cezary Cybulski

    (International Hereditary Cancer Center, Pomeranian Medical University)

  • Eleonora Fabianova

    (Regional Authority of Public Health in Banska Bystrica)

  • Viorel Jinga

    (Carol Davila University of Medicine and Pharmacy, Th. Burghele Hospital)

  • Jolanta Lissowska

    (The M Sklodowska-Curie Cancer Center and Institute of Oncology)

  • Jan Lubinski

    (International Hereditary Cancer Center, Pomeranian Medical University)

  • Marie Navratilova

    (Masaryk Memorial Cancer Institute)

  • Peter Rudnai

    (National Public Health Center, National Directorate of Environmental Health)

  • Neonila Szeszenia-Dabrowska

    (Institute of Occupational Medicine)

  • Simone Benhamou

    (Université Paris Diderot, INSERM, Unité Variabilité Génétique et Maladies Humaines)

  • Geraldine Cancel-Tassin

    (CeRePP, Tenon Hospital
    UPMC Univ Paris 06 GRC n°5)

  • Olivier Cussenot

    (CeRePP, Tenon Hospital
    UPMC Univ Paris 06 GRC n°5)

  • Laura Baglietto

    (Centre de Recherche en Épidémiologie et Santé des Populations (CESP, Inserm U1018), Université Paris-Saclay, UPS, UVSQ, Gustave Roussy)

  • Heiner Boeing

    (German Institute of Human Nutrition (DIfE) Potsdam-Rehbrücke)

  • Kay-Tee Khaw

    (University of Cambridge)

  • Elisabete Weiderpass

    (Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway
    Cancer Registry of Norway, Institute of Population-Based Cancer Research
    Karolinska Institutet
    Genetic Epidemiology Group, Folkhälsan Research Center)

  • Borje Ljungberg

    (Urology and Andrology, Umeå University)

  • Raviprakash T. Sitaram

    (Urology and Andrology, Umeå University)

  • Fiona Bruinsma

    (Cancer Epidemiology Centre, Cancer Council Victoria)

  • Susan J. Jordan

    (QIMR Berghofer Medical Research Institute
    School of Public Health, The University of Queensland)

  • Gianluca Severi

    (Centre de Recherche en Épidémiologie et Santé des Populations (CESP, Inserm U1018), Université Paris-Saclay, UPS, UVSQ, Gustave Roussy
    Cancer Epidemiology Centre, Cancer Council Victoria
    Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
    Human Genetics Foundation (HuGeF))

  • Ingrid Winship

    (The University of Melbourne
    Genetic Medicine and Family Cancer Clinic, Royal Melbourne Hospital)

  • Kristian Hveem

    (HUNT Research Centre, Norwegian University of Science and Technology)

  • Lars J. Vatten

    (Faculty of Medicine, Norwegian University of Science and Technology)

  • Tony Fletcher

    (London School of Hygiene and Tropical Medicine, University of London)

  • Kvetoslava Koppova

    (Regional Authority of Public Health in Banska Bystrica)

  • Susanna C. Larsson

    (Institute of Environmental Medicine, Karolinska Institutet)

  • Alicja Wolk

    (Institute of Environmental Medicine, Karolinska Institutet)

  • Rosamonde E. Banks

    (Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital)

  • Peter J. Selby

    (Leeds Institute of Cancer and Pathology, University of Leeds, Cancer Research Building, St James's University Hospital)

  • Douglas F. Easton

    (University of Cambridge
    University of Cambridge)

  • Paul Pharoah

    (University of Cambridge
    University of Cambridge)

  • Gabriella Andreotti

    (National Cancer Institute, National Institutes of Health)

  • Laura E. Beane Freeman

    (National Cancer Institute, National Institutes of Health)

  • Stella Koutros

    (National Cancer Institute, National Institutes of Health)

  • Demetrius Albanes

    (National Cancer Institute, National Institutes of Health)

  • Satu Männistö

    (National Institute for Health and Welfare)

  • Stephanie Weinstein

    (National Cancer Institute, National Institutes of Health)

  • Peter E. Clark

    (Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center)

  • Todd L. Edwards

    (Vanderbilt-Ingram Cancer Center, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center)

  • Loren Lipworth

    (Vanderbilt-Ingram Cancer Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center)

  • Susan M. Gapstur

    (American Cancer Society)

  • Victoria L. Stevens

    (American Cancer Society)

  • Hallie Carol

    (Dana-Farber Cancer Institute)

  • Matthew L. Freedman

    (Dana-Farber Cancer Institute)

  • Mark M. Pomerantz

    (Dana-Farber Cancer Institute)

  • Eunyoung Cho

    (Warren Alpert Medical School of Brown University)

  • Peter Kraft

    (Harvard T.H. Chan School of Public Health)

  • Mark A. Preston

    (Brigham and Women's Hospital and VA Boston)

  • Kathryn M. Wilson

    (Harvard T.H. Chan School of Public Health)

  • J. Michael Gaziano

    (Brigham and Women's Hospital and VA Boston)

  • Howard D. Sesso

    (Harvard T.H. Chan School of Public Health
    Brigham and Women's Hospital and VA Boston)

  • Amanda Black

    (National Cancer Institute, National Institutes of Health)

  • Neal D. Freedman

    (National Cancer Institute, National Institutes of Health)

  • Wen-Yi Huang

    (National Cancer Institute, National Institutes of Health)

  • John G. Anema

    (Spectrum Health)

  • Richard J. Kahnoski

    (Spectrum Health)

  • Brian R. Lane

    (Spectrum Health
    College of Human Medicine, Michigan State University)

  • Sabrina L. Noyes

    (Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology)

  • David Petillo

    (Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology)

  • Bin Tean Teh

    (Van Andel Research Institute, Center for Cancer Genomics and Quantitative Biology)

  • Ulrike Peters

    (Cancer Prevention Program, Fred Hutchinson Cancer Research Center)

  • Emily White

    (Cancer Prevention Program, Fred Hutchinson Cancer Research Center)

  • Garnet L. Anderson

    (Cancer Prevention Program, Fred Hutchinson Cancer Research Center)

  • Lisa Johnson

    (Cancer Prevention Program, Fred Hutchinson Cancer Research Center)

  • Juhua Luo

    (School of Public Health Indiana University Bloomington)

  • Julie Buring

    (Harvard T.H. Chan School of Public Health
    Brigham and Women's Hospital and VA Boston)

  • I-Min Lee

    (Harvard T.H. Chan School of Public Health
    Brigham and Women's Hospital and VA Boston)

  • Wong-Ho Chow

    (The University of Texas MD Anderson Cancer Center)

  • Lee E. Moore

    (National Cancer Institute, National Institutes of Health)

  • Christopher Wood

    (The University of Texas M.D. Anderson Cancer Center)

  • Timothy Eisen

    (Cambridge University Hospitals NHS Foundation Trust)

  • Marc Henrion

    (Icahn School of Medicine at Mount Sinai)

  • James Larkin

    (Medical Oncology, Royal Marsden NHS Foundation Trust)

  • Poulami Barman

    (Mayo Clinic)

  • Bradley C. Leibovich

    (Mayo Medical School and Mayo Clinic)

  • Toni K. Choueiri

    (Dana-Farber Cancer Institute)

  • G. Mark Lathrop

    (McGill University and Genome Quebec Innovation Centre)

  • Nathaniel Rothman

    (National Cancer Institute, National Institutes of Health)

  • Jean-Francois Deleuze

    (Centre National de Genotypage, Institut de Genomique, Commissariat à l'Energie Atomique et aux Energies Alternatives
    Fondation Jean Dausset-Centre d'Etude du Polymorphisme Humain)

  • James D. McKay

    (International Agency for Research on Cancer (IARC))

  • Alexander S. Parker

    (Mayo Clinic)

  • Xifeng Wu

    (The University of Texas MD Anderson Cancer Center)

  • Richard S. Houlston

    (The Institute of Cancer Research
    The Institute of Cancer Research)

  • Paul Brennan

    (International Agency for Research on Cancer (IARC))

  • Stephen J. Chanock

    (National Cancer Institute, National Institutes of Health)

Abstract

Previous genome-wide association studies (GWAS) have identified six risk loci for renal cell carcinoma (RCC). We conducted a meta-analysis of two new scans of 5,198 cases and 7,331 controls together with four existing scans, totalling 10,784 cases and 20,406 controls of European ancestry. Twenty-four loci were tested in an additional 3,182 cases and 6,301 controls. We confirm the six known RCC risk loci and identify seven new loci at 1p32.3 (rs4381241, P=3.1 × 10−10), 3p22.1 (rs67311347, P=2.5 × 10−8), 3q26.2 (rs10936602, P=8.8 × 10−9), 8p21.3 (rs2241261, P=5.8 × 10−9), 10q24.33-q25.1 (rs11813268, P=3.9 × 10−8), 11q22.3 (rs74911261, P=2.1 × 10−10) and 14q24.2 (rs4903064, P=2.2 × 10−24). Expression quantitative trait analyses suggest plausible candidate genes at these regions that may contribute to RCC susceptibility.

Suggested Citation

  • Ghislaine Scelo & Mark P. Purdue & Kevin M. Brown & Mattias Johansson & Zhaoming Wang & Jeanette E. Eckel-Passow & Yuanqing Ye & Jonathan N. Hofmann & Jiyeon Choi & Matthieu Foll & Valerie Gaborieau &, 2017. "Genome-wide association study identifies multiple risk loci for renal cell carcinoma," Nature Communications, Nature, vol. 8(1), pages 1-9, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15724
    DOI: 10.1038/ncomms15724
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    Cited by:

    1. Karl Smith-Byrne & Åsa Hedman & Marios Dimitriou & Trishna Desai & Alexandr V. Sokolov & Helgi B. Schioth & Mine Koprulu & Maik Pietzner & Claudia Langenberg & Joshua Atkins & Ricardo Cortez Penha & J, 2024. "Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Molly Went & Amit Sud & Charlie Mills & Abi Hyde & Richard Culliford & Philip Law & Jayaram Vijayakrishnan & Ines Gockel & Carlo Maj & Johannes Schumacher & Claire Palles & Martin Kaiser & Richard Hou, 2024. "Phenome-wide Mendelian randomisation analysis of 378,142 cases reveals risk factors for eight common cancers," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    3. Yaohua Yang & Yaxin Chen & Shuai Xu & Xingyi Guo & Guochong Jia & Jie Ping & Xiang Shu & Tianying Zhao & Fangcheng Yuan & Gang Wang & Yufang Xie & Hang Ci & Hongmo Liu & Yawen Qi & Yongjun Liu & Dan L, 2024. "Integrating muti-omics data to identify tissue-specific DNA methylation biomarkers for cancer risk," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    4. Huanhuan Cui & Hongyang Yi & Hongyu Bao & Ying Tan & Chi Tian & Xinyao Shi & Diwen Gan & Bin Zhang & Weizheng Liang & Rui Chen & Qionghua Zhu & Liang Fang & Xin Gao & Hongda Huang & Ruijun Tian & Silk, 2022. "The SWI/SNF chromatin remodeling factor DPF3 regulates metastasis of ccRCC by modulating TGF-β signaling," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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