IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v8y2017i1d10.1038_ncomms15674.html
   My bibliography  Save this article

Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus

Author

Listed:
  • Petraleigh Pantoja

    (Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus
    University of Puerto Rico-Medical Sciences Campus)

  • Erick X. Pérez-Guzmán

    (University of Puerto Rico-Medical Sciences Campus)

  • Idia V. Rodríguez

    (Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus)

  • Laura J. White

    (University of North Carolina-Chapel Hill)

  • Olga González

    (Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus)

  • Crisanta Serrano

    (University of Puerto Rico-Medical Sciences Campus)

  • Luis Giavedoni

    (Texas Biomedical Research Institute)

  • Vida Hodara

    (Texas Biomedical Research Institute)

  • Lorna Cruz

    (Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus)

  • Teresa Arana

    (University of Puerto Rico-Medical Sciences Campus)

  • Melween I. Martínez

    (Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus)

  • Mariah A. Hassert

    (Saint Louis University School of Medicine)

  • James D. Brien

    (Saint Louis University School of Medicine)

  • Amelia K. Pinto

    (Saint Louis University School of Medicine)

  • Aravinda de Silva

    (University of North Carolina-Chapel Hill)

  • Carlos A. Sariol

    (Unit of Comparative Medicine, Caribbean Primate Research Center, University of Puerto Rico-Medical Sciences Campus
    University of Puerto Rico-Medical Sciences Campus
    University of Puerto Rico-Medical Sciences Campus)

Abstract

Zika virus (ZIKV) is a re-emerging virus that has recently spread into dengue virus (DENV) endemic regions and cross-reactive antibodies (Abs) could potentially affect ZIKV pathogenesis. Using DENV-immune serum, it has been shown in vitro that antibody-dependent enhancement (ADE) of ZIKV infection can occur. Here we study the effects of pre-existing DENV immunity on ZIKV infection in vivo. We infect two cohorts of rhesus macaques with ZIKV; one cohort has been exposed to DENV 2.8 years earlier and a second control cohort is naïve to flaviviral infection. Our results, while confirming ADE in vitro, suggest that pre-existing DENV immunity does not result in more severe ZIKV disease. Rather our results show a reduction in the number of days of ZIKV viremia compared to naïve macaques and that the previous exposure to DENV may result in modulation of the immune response without resulting in enhancement of ZIKV pathogenesis.

Suggested Citation

  • Petraleigh Pantoja & Erick X. Pérez-Guzmán & Idia V. Rodríguez & Laura J. White & Olga González & Crisanta Serrano & Luis Giavedoni & Vida Hodara & Lorna Cruz & Teresa Arana & Melween I. Martínez & Ma, 2017. "Zika virus pathogenesis in rhesus macaques is unaffected by pre-existing immunity to dengue virus," Nature Communications, Nature, vol. 8(1), pages 1-13, August.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15674
    DOI: 10.1038/ncomms15674
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms15674
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms15674?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ellen Young & Boyd Yount & Petraleigh Pantoja & Sandra Henein & Rita M. Meganck & Jennifer McBride & Jennifer E. Munt & Thomas J. Baric & Deanna Zhu & Trevor Scobey & Stephanie Dong & Longping V. Tse , 2023. "A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms15674. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.